| dc.creator |
Dogru, Atalay |
|
| dc.creator |
Balkarli, Ayse |
|
| dc.creator |
Karatay, Cemile Canan |
|
| dc.creator |
Cobankara, Veli |
|
| dc.creator |
ŞAHİN, Mehmet |
|
| dc.date |
2019-07-03T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:49:03Z |
|
| dc.date.available |
2020-10-06T10:49:03Z |
|
| dc.identifier |
939337fb-c686-40c4-a258-11259d63d7eb |
|
| dc.identifier |
10.1080/17843286.2018.1495389 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/939337fb-c686-40c4-a258-11259d63d7eb/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/66629 |
|
| dc.description |
Objective: The objective of the study is to evaluate the relation of gout with osteoporosis and serum osteocalcin (OC) levels. Material and methods: Seventy-five patients diagnosed with gout and 55 controls were included in the study. Comorbid conditions and drugs associated with osteoporosis were excluded. The T and Z scores from lumbar spine (L2-L4) and femur (neck, ward, trochanter, total) were determined by dual-energy X-ray absorptiometry (DXA). OC levels were measured by enzyme-linked immunosorbent assay. Results: Osteoporosis according to T scores of lumbar vertebrae L2-L4 was found to be significantly higher in patients with gout compared to the control group (p = 0.02). Lumbar spine T-score was -1.6 in gout group and -1.0 in controls. OC level was 7.9 ng/mL in the gout group and 18.9 ng/mL in the control group. There was a significant difference (p < 0.001). In addition, mean OC level was 12.4 +/- 6.9 ng/mL in the patients diagnosed with osteoporosis and 17.2 +/- 10.6 ng/mL in the patients that were classified as normal and a significant difference was established between the two groups (p = 0.03). A significant negative correlation was found between OC level and body mass index, age, and age at first attack. Similarly, femoral T-score established a negative correlation with parathyroid hormone, age, age at first attack, and allopurinol dose. Conclusion: Serum OC level can be a useful marker in the assessment of bone turnover and clinicians should keep osteoporosis in mind in gout patients. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Bone mineral density and serum osteocalcin levels in patients with gout |
|
| dc.type |
info:eu-repo/semantics/article |
|