| dc.creator |
Kasimogullari, Rahmi |
|
| dc.creator |
Bulbul, Metin |
|
| dc.creator |
Arslan, B. Seckin |
|
| dc.creator |
Gokce, Başak |
|
| dc.date |
2010-10-31T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:49:50Z |
|
| dc.date.available |
2020-10-06T10:49:50Z |
|
| dc.identifier |
99d4b335-6322-456b-80eb-61386dd228d2 |
|
| dc.identifier |
10.1016/j.ejmech.2010.07.041 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/99d4b335-6322-456b-80eb-61386dd228d2/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/67229 |
|
| dc.description |
Pyrazole carboxylic acid derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide (inhibitor 1) were synthesized from ethyl 3-(chlorocarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-4-carboxylate compound. The inhibitory effects of inhibitor 1, acetazolamide (AAZ) and of 11 newly synthesized amides (5a-b, 6, 7a-g, and 8) on hydratase and esterase activities of carbonic anhydrase isoenzymes (hCA-I and hCA-II) have been studied in vitro. The comparison of newly synthesized amides to inhibitor 1 and to AAZ indicated that the new derivatives inhibit CA isoenzymes and they are more potent inhibitors than the parent inhibitor 1 and AAZ. (C) 2010 Elsevier Masson SAS. All rights reserved. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide |
|
| dc.type |
info:eu-repo/semantics/article |
|