| dc.creator |
ŞAHİN, Mehmet |
|
| dc.creator |
Uguz, A. Cihangir |
|
| dc.creator |
NAZIROĞLU, Mustafa |
|
| dc.creator |
Demirkan, Ilalil |
|
| dc.date |
2011-02-28T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:50:41Z |
|
| dc.date.available |
2020-10-06T10:50:41Z |
|
| dc.identifier |
a0783603-7d20-45b4-b48c-5636f3cfc855 |
|
| dc.identifier |
10.1007/s00232-011-9342-1 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/a0783603-7d20-45b4-b48c-5636f3cfc855/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/67861 |
|
| dc.description |
We investigated the effects of colchicine on oxidative stress and Ca2+ release in serum and polymorphonuclear leucocytes (PMNs) of Familial Mediterranean Fever (FMF) patients with attack, remission and unremission periods. Eighteen FMF patients and six age-matched healthy subjects in four groups were used. The first group was a control. The second group included patients with active FMF. The third and fourth groups were patients with remission and unremission, respectively. Colchicine (1.5 mg/day) was given to the third and fourth groups for 1 month. PMN cells, serum lipid peroxidation and intracellular Ca2+-release levels in the attack and unremission groups were higher than in those in controls, although they were lower in the remission group than in the attack group. Serum vitamin E and beta-carotene concentrations were higher in the remission group than in the control and attack groups. However, PMN, serum lipid peroxidation and Ca2+-release levels were further increased in the unremission group compared to the attack group. Glutathione peroxidase, reduced glutathione and vitamin A values in the four groups did not change by FMF and colchicine. In conclusion, we observed that colchicine induced protective effects on oxidative stress by modulating vitamin E, beta-carotene and Ca2+-release levels in FMF patients with a remission period. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Colchicine Modulates Oxidative Stress in Serum and Leucocytes from Remission Patients with Family Mediterranean Fever Through Regulation of Ca2+ Release and the Antioxidant System |
|
| dc.type |
info:eu-repo/semantics/article |
|