| dc.creator |
Tekeli, Alper |
|
| dc.creator |
Ozseven, Ayse Gul |
|
| dc.creator |
Us, Ebru |
|
| dc.creator |
Cetin, Emel |
|
| dc.creator |
Aridogan, Buket |
|
| dc.date |
2013-10-31T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:51:10Z |
|
| dc.date.available |
2020-10-06T10:51:10Z |
|
| dc.identifier |
a4105ce1-4424-4ff0-b745-d0610d05ac7e |
|
| dc.identifier |
10.7883/yoken.66.463 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/a4105ce1-4424-4ff0-b745-d0610d05ac7e/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/68230 |
|
| dc.description |
The aim of this study was to investigate the in vitro activities of polymyxin B (PB) and rifampin (RIF) in combination with ampicillin/sulbactam (AS) or cefoperazone/sulbactam (CS) against 20 multidrug-resistant Acinetobacter baumannii (MDR-AB) isolates by the checkerboard and E-test methods. Fractional inhibitory concentration index (FICI) values were defined as synergy, FICI <= 0.5; additivity, 0.5 < FICI <= 1.0, indifference, 1.0 < FICI < 4.0; and antagonism, FICI >= 4. Synergistic interaction was detected only for the RIF + AS and RIF + CS combinations. While the most frequently detected interaction type for PB + AS or PB + CS combinations was indifference, some showed antagonistic interactions. The detection rate of synergy was significantly higher by the checkerboard than by the E-test method, and the detection rate of indifference was significantly higher by the E-test than by the checkerboard method for RIF + AS combination (P <= 0.0001). In addition, no statistically significant difference was detected between the checkerboard and E-test methods for the detection rates of interaction types for any of the other combinations (P > 0.05), except for PB + CS combination for the detection of additivity (P = 0.018). Owing to the high percentage of synergistic interactions between RIF and AS, we considered this combination as an effective therapeutic option for MDR-AB infections. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.title |
Determination of In Vitro Activities of Polymyxin B and Rifampin in Combination with Ampicillin/Sulbactam or Cefoperazone/Sulbactam against Multidrug-Resistant Acinetobacter baumannii by the E-test and Checkerboard Methods |
|
| dc.type |
info:eu-repo/semantics/article |
|