| dc.creator |
Muallaoglu, Sadik |
|
| dc.creator |
Kocer, Murat |
|
| dc.creator |
Guler, Nilufer |
|
| dc.date |
2012-05-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:51:23Z |
|
| dc.date.available |
2020-10-06T10:51:23Z |
|
| dc.identifier |
a5d67950-ddda-4ee5-99e2-8baf553773fe |
|
| dc.identifier |
10.1007/s12032-011-9956-2 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/a5d67950-ddda-4ee5-99e2-8baf553773fe/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/68401 |
|
| dc.description |
Paclitaxel is highly active against a variety of solid tumors including breast lung, ovarian and head and neck cancer. Although peripheral neurotoxicity is well-known side effect, central nervous system (CNS) toxicity-related standard dose of paclitaxel is extremely uncommon, because paclitaxel dose not cross the blood-brain barrier and is not detectable in the cerebrospinal fluid. We present a patient with advanced stage breast carcinoma who developed acute and spontaneous resolving encephalopathy after weekly dose of paclitaxel. The patient did not have brain metastasis, or prior whole-brain irradiation, or any type of neurosurgery. Radiological imaging studies showed no abnormalities. CNS toxicity of paclitaxel should be kept in mind in patients without a previous history of brain metastasis or brain irradiation and even with low weekly doses. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Acute transient encephalopathy after weekly paclitaxel infusion |
|
| dc.type |
info:eu-repo/semantics/article |
|