| dc.creator |
Guney, Mehmet |
|
| dc.creator |
Bayhan, Gokhan |
|
| dc.creator |
Oral, Baha |
|
| dc.creator |
Altuntas, Irfan |
|
| dc.creator |
Demirin, Hilmi |
|
| dc.creator |
Ozguner, Meltem |
|
| dc.date |
2007-05-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T11:01:30Z |
|
| dc.date.available |
2020-10-06T11:01:30Z |
|
| dc.identifier |
b622c285-0eca-448d-80e3-14e79a9a79ee |
|
| dc.identifier |
10.1177/0960327106077505 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/b622c285-0eca-448d-80e3-14e79a9a79ee/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/70049 |
|
| dc.description |
We have investigated the effect of subchronic administration of methidathion (MD) on ovary evaluated ameliorating effects of vitamins E and C against MD toxicity. Experimental groups were as follows: control group; a group treated with 5 mg/kg body weight MD (MD group); and a group treated with 5 mg/kg body weight MD plus vitamin E and vitamin C (MD + Vit group). MD and MD + Vit groups were given MD by gavage five days a week for four weeks at a dose level of 5 mg/kg/day by using corn oil as the vehicle. Serum malondialdehyde (MDA: an indicator of lipid peroxidation) concentration, serum activity of cholinesterase (ChE), and ovary histopathology were studied. The level of MDA increased significantly in the MD group compared with the control (P < 0.005). Serum MDA decreased significantly in the MD + Vit group compared with the MD group (P < 0.05). The activities of ChE decreased significantly both in the MD and MD + Vit groups compared with the controls (P < 0.05). However, the decrease in the MD + Vit groups was less than in the MD group; the ChE activity in the MD + Vit group was significantly higher compared with MD group (P < 0.05). Number of ovarian follicles were significantly lower in the MD group compared to the controls (P < 0.05). Number of atretic follicles were significantly higher in the MD group than in the controls (P < 0.05). Follicle counts in MD + Vit group showed that all types of ovarian follicles were significantly higher, and a significant decrease in the number of atretic follicles compared with the MD group (P < 0.05). In conclusion, subchronic MD administration caused an ovarian damage, in addition, LPO may be one of the molecular mechanisms involved in MD-induced toxicity. Treatment with vitamins E and C after the administration of MD reduced LPO and ovarian damage. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Ovarian toxicity in rats caused by methidathion and ameliorating effect of vitamins E and C |
|
| dc.type |
info:eu-repo/semantics/article |
|