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Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro

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dc.creator Ozdem, SS
dc.creator ÜNAL, FİLİZ
dc.creator SMİTH, MARK A
dc.creator ALICIGÜZEL, YAKUP
dc.creator Kumbul, Duygu
dc.creator Ozdem, S
dc.creator DEMİR, AYŞE YASEMİN
dc.creator PERRY, GEORGE
dc.date 2000-12-31T22:00:00Z
dc.date.accessioned 2020-10-06T11:21:58Z
dc.date.available 2020-10-06T11:21:58Z
dc.identifier bdf71ea5-e21d-4c66-a437-5ddd764c7d10
dc.identifier 10.1179/135100001101536256
dc.identifier https://avesis.sdu.edu.tr/publication/details/bdf71ea5-e21d-4c66-a437-5ddd764c7d10/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/70841
dc.description To investigate the possible role of oxygen free radicals and oxidant stress in the toxic effects of phenoxyherbicides. we studied the in vitro effect of 4-chlorophenoxyacetic acid (4-CPA) on various human erythrocyte antioxidant enzymes, namely glucose-6-phosphate dehydrogenase, catalase, selenium-dependent glutathione peroxidase, glutathione reductase and Cu/Zn-superoxide dismutase. 4-CPA added in a dose of 1 ppm to human erythrocytes for 1 h caused a significant reduction in glucose-6-phosphate dehydrogenase (P <0.001) and catalase (P <0.001) activities, but did not significantly affect the activities of other enzymes. Such selective inactivation of specific erythrocyte antioxidant enzymes may play a role in the toxic effects of phenoxyherbicides.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro
dc.type info:eu-repo/semantics/article


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