| dc.creator |
ALICI, BÜLENT |
|
| dc.creator |
GÖKÇE, Başak |
|
| dc.creator |
GENÇER, NAHİT |
|
| dc.creator |
TAŞKIN TOK, TUĞBA |
|
| dc.creator |
ÖZDEMİR, NAMIK |
|
| dc.creator |
Kilic-Cikla, Isin |
|
| dc.creator |
KARATAŞ, MERT OLGUN |
|
| dc.creator |
ARSLAN, OKTAY |
|
| dc.creator |
Calgin, Gamze |
|
| dc.date |
2019-09-30T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T11:22:06Z |
|
| dc.date.available |
2020-10-06T11:22:06Z |
|
| dc.identifier |
bf26a6d9-3854-4942-bfc1-3f48d7645b9a |
|
| dc.identifier |
10.1002/aoc.5130 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/bf26a6d9-3854-4942-bfc1-3f48d7645b9a/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/70945 |
|
| dc.description |
We synthesized three coumarin-substituted benzimidazolium chlorides and their silver(I), ruthenium(II) and palladium(II) N-heterocyclic carbene (NHC) complexes. All compounds were characterized using appropriate spectroscopic techniques and elemental analyses. Single-crystal X-ray structure of a Pd(II)-NHC complex (6b) was also determined. The inhibitory properties of all compounds were tested on the activity of human paraoxonase 1 (PON1). All complexes exhibited weaker inhibitory properties than their corresponding benzimidazolium salts except for complex 6b which is the most active inhibitor with an IC50 value of 3.01 mu M among the compounds reported in this study. A kinetic evaluation showed that this complex inhibits PON1 activity in a non-competitive manner. Molecular docking studies were also performed for 6b in order to obtain more insight into the binding mode. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Inhibition of paraoxonase 1 by coumarin-substituted N-heterocyclic carbene silver(I), ruthenium(II) and palladium(II) complexes |
|
| dc.type |
info:eu-repo/semantics/article |
|