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A recurrent mutation in the ARS (Component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: Evidence of a founder effect

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dc.creator HU, GF
dc.creator YILMAZ, E
dc.creator Yildirim, Mehmet
dc.creator YEREBAKAN, O
dc.creator SERHAT INALOZ, H
dc.creator MARTINEZ-MIR, A
dc.creator CELEBI, JT
dc.creator CHRISTIANO, AM
dc.creator BAYSAL, V
dc.date 2003-05-31T21:00:00Z
dc.date.accessioned 2020-10-06T11:22:25Z
dc.date.available 2020-10-06T11:22:25Z
dc.identifier c1acbcdb-170b-41f4-87a1-2d780dbc5a49
dc.identifier 10.1046/j.1523-1747.2003.12248.x
dc.identifier https://avesis.sdu.edu.tr/publication/details/c1acbcdb-170b-41f4-87a1-2d780dbc5a49/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/71194
dc.description Mal de Meleda is a rare form of palmoplantar keratoderma, and recently mutations in the ARS (component) B gene have been identified in families with this disease. We identified a recurrent nonsense mutation, R96X, in four families of Turkish descent. In this report, we demonstrate that these families share a common ancestral haplotype at the mal de Meleda locus, suggesting a founder effect.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title A recurrent mutation in the ARS (Component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: Evidence of a founder effect
dc.type info:eu-repo/semantics/article


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