| dc.creator |
Cerci, Sevim Sureyya |
|
| dc.creator |
Tatar, Burak |
|
| dc.creator |
Erdemoglu, Ebru |
|
| dc.creator |
ERDEMOĞLU, Evrim |
|
| dc.creator |
BOZKURT, Kemal Kürşat |
|
| dc.creator |
Yalcin, Yakup |
|
| dc.date |
2015-08-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T11:22:51Z |
|
| dc.date.available |
2020-10-06T11:22:51Z |
|
| dc.identifier |
c4db0dc0-f968-4f7d-9d87-f46ddb0200ae |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/c4db0dc0-f968-4f7d-9d87-f46ddb0200ae/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/71511 |
|
| dc.description |
Objective:To study the relation between SUVmax, hypoxia inducible factor 1 alpha (HIF-1 alpha), angiogenetic factor adrenomedullin (AM) and antiapoptotic factor Bcl-2 in endometrial cancer. Subjects and Methods:Thirthy eight patients who were diagnosed after a preoperative endometrial biopsy with endometriuni cancer underwent pre-operative positron emission tomography/computed tomography (PET/CT) utilizing fluorine-18-fluorodeoxy glucose (F-18-FDG). Maximum standardized uptake values (SUVmax) of the primary tumor were measured. After hysterectomy and bilateral salpingo-oophorectomy, microscopic slides of the 38 endometrial adenocarcinoma patients were evaluated by a surgical pathologist to confirm the diagnosis. Immunohistochemical staining for AM, Bcl-2 and HIF-1 alpha was studied. Results: In all patients, F-18-FDG uptake was detected. The mean SUVmax of the tumors was 11.8 +/- 5.9. Although SUVmax was higher in HIF-1 alpha positive tumors, this finding was not statistically important. No correlation was found between SUVmax and HIF-1 alpha positivity. Mean SUVmax was 6.4 +/- 3 and 12.3 +/- 1.4 in AM negative and AM positive patients, respectively. Mean SUVmax was 10.6 +/- 4.9 and 12.3 +/- 1.4 in Bcl-2 negative and Bcl-2 positive patients, respectively.We found no correlation between SUVmax, AM or Bcl-2 expression.Allred scores were not related with SUVmax in regression analysis. Conclusion:Our study in a small number of patients is the first to show that SUVmax, although expected is not associated with HIF-1 alpha, AM or with Bcl-2 in endometrial cancer. Increased uptake of F-18-FDG in endometrial cancer seems to be independent of HIF-1 alpha and its downstream factors. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Hypoxia-inducible factor-1 alpha, adrenomedullin and Bcl-2 although expected are not related to increased uptake of fluorine-18-fluorodeoxyglucose in endometrial cancer |
|
| dc.type |
info:eu-repo/semantics/article |
|