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AN INVESTIGATION OF PREVENTIVE EFFECTS OF ROSE WATER CONTAINING ESSENTIAL ROSE OIL AGAINST TOXICOLOGICAL EFFECTS OF CHLORPYRIFOS (DURSBAN 4) ETHYL IN RATS

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dc.creator ÖZÇELİK, Hasan
dc.creator Kilinc, Dide
dc.creator ÖĞÜT, SERDAL
dc.creator Yaman, Hilmi
dc.creator Koc, Ece
dc.creator Gokcimen, Alparslan
dc.creator Deniz, Burcu
dc.creator CESUR, GÖKHAN
dc.creator TURGUT, Cafer
dc.creator BİRCAN, CAVİT
dc.date 2014-12-31T22:00:00Z
dc.date.accessioned 2020-10-06T11:24:06Z
dc.date.available 2020-10-06T11:24:06Z
dc.identifier ce9e0bf6-c852-48a5-8158-558db2d45f34
dc.identifier https://avesis.sdu.edu.tr/publication/details/ce9e0bf6-c852-48a5-8158-558db2d45f34/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/72446
dc.description In this study, it was aimed to determine the preventive effects of rose water against toxicological effects of chlorpyrifos-ethyl (CPE). Group I was the control group, group II received CPE (0.3 mg/kg/day), group III received water solution of rose extract (WR, 100 mg/kg/day), while group IV received WR + CPE. The rats were sacrificed after 15 days of the experiment to collect blood samples, liver and kidney tissue. The results showed that, compared to the CPE group, there was a significant (p<0.001) decrease in the activities of GGT, ALT, AST, lipase enzymes and MDA levels, while a significant (p<0.001) increase was observed in put the actual words (TAC) and platelet (PLT) levels in the CPE + WR group. Between the control and WR groups, TAC, WBC and CAT levels were significantly (p<0.001) higher, while TOC and OSI levels were significantly (p<0.001) lower in the WR group. The highest OSI levels were determined in the CPE group (1.12 mu mol H2O2 equ./L) followed by CPE + RW (1.02 mu mol H2O2 equ./L), (0.931 mu mol H2O2 equ./L) and RW (0.87 mu mol H2O2 equ./L) groups. PON and ARE were found to be significantly (p<0.001) low in the CPE and CPE + RW groups. In between these two groups of CPE and CPE + RW, the levels of PON and ARE were found significantly (p<0.001) higher in the CPE + RW group. A residue of CPE was also detected in the groups II and IV. In conclusion, it can be said that WR showed some positive effects on the enzymes of liver and haematological parameters in rats, and reduced the toxic effects of CPE.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title AN INVESTIGATION OF PREVENTIVE EFFECTS OF ROSE WATER CONTAINING ESSENTIAL ROSE OIL AGAINST TOXICOLOGICAL EFFECTS OF CHLORPYRIFOS (DURSBAN 4) ETHYL IN RATS
dc.type info:eu-repo/semantics/article


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