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Impact of 2.45 GHz Microwave Radiation on the Testicular Inflammatory Pathway Biomarkers in Young Rats: The Role of Gallic Acid

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dc.creator Dincoglu, Dilnur
dc.creator İLHAN, İlter
dc.creator SAYGIN, Mustafa
dc.creator CANKARA, Fatma Nihan
dc.creator AŞCI, Halil
dc.creator Ozmen, Ozlem
dc.date 2016-11-30T21:00:00Z
dc.date.accessioned 2020-10-06T11:24:22Z
dc.date.available 2020-10-06T11:24:22Z
dc.identifier d09e5d88-1d9d-4085-a531-4a145118545f
dc.identifier 10.1002/tox.22179
dc.identifier https://avesis.sdu.edu.tr/publication/details/d09e5d88-1d9d-4085-a531-4a145118545f/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/72646
dc.description The aim of this study was to investigate electromagnetic radiation (EMR) transmitted by wireless devices (2.45 GHz), which may cause physiopathological or ultrastructural changes, in the testes of rats. We addressed if the supplemental gallic acid (GA) may reduce these adverse effects. Six-week-old male Sprague Dawley rats were used in this study. Forty eight rats were equally divided into four groups, which were named: Sham, EMR only (EMR, 3 h day(-1) for 30 days), EMR1GA (30 mg/kg/daily), and GA (30 mg/kg/daily) groups. Malondialdehyde (MDA) and total oxidant status (TOS) levels increased (p=0.001 for both) in EMR only group. TOS and oxidative stress index (OSI) levels decreased in GA treated group significantly (p=0.001 and p=0.045, respectively). Total antioxidant status (TAS) activities decreased in EMR only group and increased in GA treatment group (p=0.001 and p=0.029, respectively). Testosterone and vascular endothelial growth factor (VEGF) levels decreased in EMR only group, but this was not statistically significant. Testosterone and VEGF levels increased in EMR1GA group, compared with EMR only group (p=0.002), and also increased in GA group compared with the control and EMR only group (p=0.044 and p=0.032, respectively). Prostaglandin E-2 (PGE(2)) and calcitonin gene releated peptide (CGRP) staining increased in tubules of the testes in EMR only group (p<0.001 for both) and decreased in tubules of the testes in EMR1GA group (p<0.001 for all parameters). In EMR only group, most of the tubules contained less spermatozoa, and the spermatozoon counts decreased in tubules of the testes. All these findings and the regenerative reaction, characterized by mitotic activity, increased in seminiferous tubules cells of the testes in EMR1GA group (p<0.001). Long term EMR exposure resulted in testicular physiopathology via oxidative damage and inflammation. GA may have ameliorative effects on the prepubertal rat testes physiopathology. (C) 2015 Wiley Periodicals, Inc.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Impact of 2.45 GHz Microwave Radiation on the Testicular Inflammatory Pathway Biomarkers in Young Rats: The Role of Gallic Acid
dc.type info:eu-repo/semantics/article

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