| dc.creator |
Koyu, A |
|
| dc.creator |
Caliskan, S |
|
| dc.creator |
Ozguner, F |
|
| dc.creator |
Karaca, H |
|
| dc.date |
2005-09-30T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T11:24:42Z |
|
| dc.date.available |
2020-10-06T11:24:42Z |
|
| dc.identifier |
d32e5f7b-ef65-4a96-88f1-07413588f60e |
|
| dc.identifier |
10.1191/0748233705th233oa |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/d32e5f7b-ef65-4a96-88f1-07413588f60e/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/72872 |
|
| dc.description |
Although iron (Fe), plays an important role in different oxidative steps during the metabolism of the human body, it can cause free radical damage. Iron ions seem to play a major role in initiation and promotion reactions of intracellular lipid peroxidation. The aim of this study was to investigate if vitamin E has a protective effect on oxidative changes in erythrocytes induced by Fe treatment. Thirty mate New Zealand white rabbits weighing 1400 +/- 50 g were used in the study. The animals were divided into three groups. The first group (n : 10) was given 500 mg/kg iron-dextran through intraperitoneal (ip) injection. The second group was given 500 mg/kg iron-dextran + 100 mg/kg vitamin E(ip). The third group constituted the control group and received a saline solution injection. The activities of erythrocyte antioxidant enzymes; Superoxide Dismutase (SOD), Glutatione peroxidase (GSH-Px), Catalase (CAT) and Malondialdehyde (MDA) level, an indicator of lipid peroxidation, were determined. Erythrocyte SOD, GSH-Px and CAT activities were decreased and MDA level was increased in iron-dextran treated animals compared to the control group (P < 0.05). The activities of the three antioxidant enzymes were increased and MDA level was decreased in iron-dextran and vitamin E treated group compared to the control group (P < 0.05). |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Preventive effect of vitamin E on iron-induced oxidative damage in rabbit |
|
| dc.type |
info:eu-repo/semantics/article |
|