| dc.creator |
KARATAŞ, MERT OLGUN |
|
| dc.creator |
ALICI, BÜLENT |
|
| dc.creator |
Arslan, Oktay |
|
| dc.creator |
Gencer, Nahit |
|
| dc.creator |
GÖKÇE, Başak |
|
| dc.date |
2015-12-31T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T11:25:52Z |
|
| dc.date.available |
2020-10-06T11:25:52Z |
|
| dc.identifier |
dc2e3b61-99a9-4932-a04e-dad433d83a52 |
|
| dc.identifier |
10.3109/14756366.2015.1043297 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/dc2e3b61-99a9-4932-a04e-dad433d83a52/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/73765 |
|
| dc.description |
Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. In this study, in vitro effect of some hydroxy and dihydroxy ionic coumarin derivatives (1-20) on purified PON1 activity was investigated. Among these compounds, derivatives 11-20 are water soluble. In investigated compounds, compounds 6 and 13 were found the most active (IC50 = 35 and 34 mu M) for PON1, respectively. The present study has demonstrated that PON1 activity is very highly sensitive to studied coumarin derivatives. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1) |
|
| dc.type |
info:eu-repo/semantics/article |
|