| dc.creator |
Sonmez, Fatih |
|
| dc.creator |
Kucukislamoglu, Mustafa |
|
| dc.creator |
Ergun, Adem |
|
| dc.creator |
Gencer, Nahit |
|
| dc.creator |
Arslan, Oktay |
|
| dc.creator |
GÖKÇE, Başak |
|
| dc.creator |
Demir, Taki |
|
| dc.creator |
Kurt, Belma Z. |
|
| dc.date |
2016-08-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T11:26:05Z |
|
| dc.date.available |
2020-10-06T11:26:05Z |
|
| dc.identifier |
ddd83b35-cee2-417a-bbc2-38f197f40a41 |
|
| dc.identifier |
10.1134/s1068162016050046 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/ddd83b35-cee2-417a-bbc2-38f197f40a41/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/73929 |
|
| dc.description |
Coumarin and heterocyclic compounds incorporating urea have clinical applications as antiepileptics, diuretics, and antiglaucoma agents due to their carbonic anhydrase inhibitory properties. We investigated inhibition of carbonic anhydrase I and II with a series of coumarylthiazole derivatives containing urea/thiourea groups. All the investigated compounds exhibited inhibitory activity on both hCA I and hCA II, with 1-(3-chlorophenyl)-3-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)urea being the strongest inhibitor. Structure-activity relationship study showed that most of urea derivatives were more inhibiting for hCA I and hCA II than thiourea derivatives. The electron-withdrawing groups at the phenyl ring increased the inhibitory activity compared to electron-donating groups. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives |
|
| dc.type |
info:eu-repo/semantics/article |
|