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The comparative study of the DNA binding and biological activities of the quaternized dicnq as a dicationic form and its platinum(II) heteroleptic cationic complex

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dc.creator Coban, Burak
dc.creator Kandemir, Irfan
dc.creator Sengul, Abdurrahman
dc.creator Comert, Fusun
dc.creator AKKOÇ, Senem
dc.creator Yildiz, Ufuk
dc.date 2019-05-31T21:00:00Z
dc.date.accessioned 2020-10-06T11:37:34Z
dc.date.available 2020-10-06T11:37:34Z
dc.identifier e37c4670-ebc2-4aa0-9e9b-ceb6301e9c3f
dc.identifier 10.1016/j.bioorg.2019.03.009
dc.identifier https://avesis.sdu.edu.tr/publication/details/e37c4670-ebc2-4aa0-9e9b-ceb6301e9c3f/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/74495
dc.description The square-planar heteroleptic Pt(II) coordination compound [Pt(bpy)(dicnq)](NO3)(2) (1) and the quaternized dicnq ligand, namely 12,13-dicyano-5,6-dihydrodipyrazino[2,3-f:1',2',3',4'-lmn] [1,10] phenanthroline-4,7-diium dibromide (2) (Fig. 1) were synthesized and fully characterized by means of FTIR, NMR, MALDI-TOF MS and the purity was confirmed by CHN analyses. The DNA binding profiles of 1 and 2 were identified in an identical condition. The biological activities of these compounds were investigated by the assays of transcription and replication inhibition, cytotoxic and antimicrobial activity.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title The comparative study of the DNA binding and biological activities of the quaternized dicnq as a dicationic form and its platinum(II) heteroleptic cationic complex
dc.type info:eu-repo/semantics/article


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