| dc.creator |
Canatan, Duran |
|
| dc.creator |
Gedikli, Omer |
|
| dc.creator |
Altinbas, Ahmet |
|
| dc.creator |
Orucoglu, Aslihan |
|
| dc.creator |
Dogan, Abdullah |
|
| dc.creator |
Ozaydin, Mehmet |
|
| dc.creator |
Acar, Gurkan |
|
| dc.creator |
Aslan, Suleyman Murat |
|
| dc.date |
2007-08-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T11:38:15Z |
|
| dc.date.available |
2020-10-06T11:38:15Z |
|
| dc.identifier |
e8755fb8-f91a-4da3-91bd-4a4a3de38a4a |
|
| dc.identifier |
10.1111/j.1540-8175.2007.00486.x |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/e8755fb8-f91a-4da3-91bd-4a4a3de38a4a/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/74996 |
|
| dc.description |
Background: beta-thalassemia major (beta-TM) is a congenital hemolytic disorder characterized by impaired left ventricular and endothelial function. However, elastic properties of the aorta have not been sufficiently investigated in patients with beta-TM. We investigated whether beta-TM is related to impaired ascending aortic elastic properties. Methods: We studied 36 patients with beta-TM (age: 15.8 +/- 2.6 years) and 30 age- and sex-matched control subjects by echocardiography. Aortic elastic indexes, aortic strain (%), distensibility (cm(2) dyn(-1) 10(-3)), and stiffness index were calculated from the echocardiographically derived thoracic aortic diameters (mm/m(2)), and the measurement of pulse pressure obtained by cuff sphygmomanometry. Results: Patients versus control subjects had increased aortic diameters (P < 0.001), lower mean aortic strain (9 +/- 3.6 vs. 14.9 +/- 3.2, P < 0.001) and distensibility (0.6 +/- 0.36 vs. 0.8 +/- 0.2, P < 0.012), and higher mean stiffness index (5.3 +/- 2.4 vs. 2.8 +/- 0.6, P < 0.001). Aortic elastic indexes were significantly associated with ferritin level, while stiffness index was significantly related to platelet count. Conclusion: Elastic properties of ascending aorta are impaired in patients with beta-TM. Impaired functions of aorta may lead to deterioration of left ventricular function. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Elastic properties of the ascending aorta in patients with beta-thalassemia major |
|
| dc.type |
info:eu-repo/semantics/article |
|