| dc.creator |
TEMELLI, Basak |
|
| dc.creator |
AKSOY, Fatih |
|
| dc.creator |
USKUN, Ersin |
|
| dc.creator |
SAVAS, Hasan Basri |
|
| dc.creator |
VAROL, Ercan |
|
| dc.creator |
YETKİN AY, Zuhal |
|
| dc.creator |
KUMBUL DOĞUÇ, Duygu |
|
| dc.date |
2017-12-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T11:38:17Z |
|
| dc.date.available |
2020-10-06T11:38:17Z |
|
| dc.identifier |
e8950b70-4a59-473a-8f5b-5a28165ef828 |
|
| dc.identifier |
10.1590/1678-7757-2017-0322 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/e8950b70-4a59-473a-8f5b-5a28165ef828/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/75014 |
|
| dc.description |
Objectives: One of the plausible mechanisms in the relationship between periodontitis and coronary artery disease (CAD) is the systemic inflammatory burden comprised of circulating cytokines/mediators related to periodontitis. This study aims to test the hypothesis that periodontal inflamed surface area (PISA) is correlated with higher circulating levels of acute phase reactants (APR) and pro-inflammatory cytokines/mediators and lower anti-inflammatory cytokines/mediators in CAD patients. Material and Methods: Patients aged from 30 to 75 years who underwent coronary angiography with CAD suspicion were included. Clinical periodontal parameters (probing depth - PD, clinical attachment loss, and bleeding on probing - BOP) were previously recorded and participants were divided into four groups after coronary angiography: Group 1: CAD (+) with periodontitis (n=20); Group 2: CAD (+) without periodontitis (n=20); Group 3: CAD (-) with periodontitis (n=21); Group 4: CAD (-) without periodontitis (n = 16). Serum interleukin (IL) -1, -6, -10, tumor necrosis factor (TNF)-a, serum amyloid A (SAA), pentraxin (PTX) 3, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with ELISA. Results: Groups 1 and 3 showed periodontal parameter values higher than Groups 2 and 4 (p<0.0125). None of the investigated serum parameters were statistically significantly different between the study groups (p>0.0125). In CAD (-) groups (Groups 3 and 4), PISA has shown positive correlations with PTX3 and SAA (p<0.05). Age was found to predict CAD significantly according to the results of the multivariate regression analysis (Odds Ratio: 1.17; 95% Confidence Interval: 1.08-1.27; p<0.001). Conclusions: Although age was found to predict CAD significantly, the positive correlations between PISA and APR in CAD (-) groups deserve further attention, which might depend on the higher PISA values of periodontitis patients. In further studies conducted in a larger population, the stratification of age groups would provide us more accurate results. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area |
|
| dc.type |
info:eu-repo/semantics/article |
|