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<p><strong>Assocıatıon between oral cancer and oral microbiata</strong></p><p> </p><p>The role that bacteria play in the etiology and predisposition to cancer is of increasing interest, particularly since the development of high-throughput geneticbased assays. This review outlines our understanding of the link between the oral microbiome and oral cancer. Although the microbiome includes all organisms of the oral cavity, including viruses, fungi, and archaea, this article focuses on the understanding of bacteria and its association with oral squamous cell carcinoma. (OSCC). Poor oral hygiene and periodontal disease has been long been linked with carcinoma of the oral cavity. Although there is increasing evidence that the OSCC is associated with changes in the oral microbiome, there is currently no consensus regarding specific changes in the bacterial species. In some researches, it was seen that in OSCC and precancer patient the microbiome over the tumor had a significant reduction in the abundance of <em>Firmicutes</em> represented by <em>Streptococcus </em>and <em>Actinobacteria</em> represented by <em>Rothia</em>, and an increase in the abundance of <em>Fusobacteria</em> represented by <em>Fusobacterium</em> when compared with the normal contralateral sample, a difference that is not present in noncancer patients. Despite increasing technology and interest in the relationships between the oral microbiome and the development of oral cancer, much remains to be done. Although it is apparent that the oral microbiome differs between normal and OSCC patients, no pathognomonic bacterial or bacterial spectrum has yet been identified in OSCC.</p><p> </p> |
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