| dc.creator |
Ozkan, Seyda Cigdem |
|
| dc.creator |
Yilmaz, Aydan |
|
| dc.creator |
ÖZMEN, İsmail |
|
| dc.date |
2014-01-01T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T12:02:11Z |
|
| dc.date.available |
2020-10-06T12:02:11Z |
|
| dc.identifier |
f3898903-7b39-4e8a-8402-236b1517055b |
|
| dc.identifier |
10.1080/10610278.2013.817578 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/f3898903-7b39-4e8a-8402-236b1517055b/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/76095 |
|
| dc.description |
This study comprises the synthesis of new p-tert-butylcalix[4]arene with different amide functional groups and summarises an investigation of their DNA cleavage activities. The structural investigations of the synthesised compounds were examined by FTIR, H-1 NMR, C-13 NMR, elemental analysis and FAB-MS techniques. The interaction between these compounds and pBR322 plasmid DNA has been investigated via agarose gel electrophoresis and, according to the results, compounds 5, 7, 8 and 13 exhibit efficient DNA cleavage activity. In the electrophoresis images of 5, 7 and 8, Form IV which is small DNA fragment was observed in addition to supercoiled Form I, open circular Form II and linear Form III. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Synthesis of new calix[4] arene amide derivatives and investigation of their DNA cleavage activity |
|
| dc.type |
info:eu-repo/semantics/article |
|