| dc.creator |
Akkoc, Senem |
|
| dc.creator |
Kayser, Veysel |
|
| dc.creator |
Hawkins, Bryson |
|
| dc.creator |
Williams, Peter A. |
|
| dc.creator |
Hibbs, David E. |
|
| dc.creator |
Lai, Felcia |
|
| dc.creator |
GÖK, YETKİN |
|
| dc.creator |
İLHAN, İLHAN ÖZER |
|
| dc.date |
2017-06-14T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T12:02:52Z |
|
| dc.date.available |
2020-10-06T12:02:52Z |
|
| dc.identifier |
f897321b-bc21-4b2b-b711-c26abb448de0 |
|
| dc.identifier |
10.1016/j.jorganchem.2017.03.037 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/f897321b-bc21-4b2b-b711-c26abb448de0/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/76607 |
|
| dc.description |
Benzimidazolium salts and their Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) palladium N-heterocyclic carbene (Pd-NHC) based complexes have been synthesized and their structures characterized with a number of different instrumental techniques including NMR (H-1 and C-13), IR, EI-MS (for 2), X-ray (for 1, 2 and 4) and elemental analysis. The cytotoxicity of all the compounds was tested using the human embryonic kidney (HEK-293T), human breast epithelial adenocarcinoma (MDA-MB-231), and human colon epithelial colorectal adenocarcinoma (DLD-1) cell lines. The benzimidazolium salts (2-5) had more cytotoxic activity against cancerous cells compared with the metal complexes (6-9), which curiously exhibited no activity against any of the cell lines. Based on the IC50 values, compound 5 displayed the highest in vitro anticancer activity among compounds 2-9. Crown Copyright (C) 2017 Published by Elsevier B.V. All rights reserved. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
New compounds based on a benzimidazole nucleus: synthesis, characterization and cytotoxic activity against breast and colon cancer cell lines |
|
| dc.type |
info:eu-repo/semantics/article |
|