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Catastrophic antiphospholipid syndrome treated with rituximab: A case report

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dc.creator ŞAHİN, Mehmet
dc.creator Ugan, Yunus
dc.creator KARAHAN, Nermin
dc.creator Tunc, Sevket Ercan
dc.creator DOĞRU, Atalay
dc.date 2017-05-31T21:00:00Z
dc.date.accessioned 2020-10-06T12:02:55Z
dc.date.available 2020-10-06T12:02:55Z
dc.identifier f8c728b6-2e3a-41e4-acdc-3d1477a5d173
dc.identifier 10.5152/eurjrheum.2017.160073
dc.identifier https://avesis.sdu.edu.tr/publication/details/f8c728b6-2e3a-41e4-acdc-3d1477a5d173/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/76626
dc.description Catastrophic antiphospholipid syndrome (CAPS) is a rare and fatal condition that is characterized by diffuse venous and/or arterial thromboembolism within a short period of time and histopathological confirmation of small-vessel occlusion in at least one organ or tissue in the presence of positive antiphospholipid antibodies. Here we report the case of a 19-year-old woman with CAPS. During the first week of her hospitalization, she was diagnosed with CAPS on the basis of skin necrosis, pulmonary artery thrombosis, cerebral venous sinus thrombosis, and positive lupus anticoagulant. She was treated with corticosteroids, intravenous immunoglobulins, plasmapheresis, and anticoagulants. Forty days after the onset of CAPS, cutaneous lesions were recurred during skin surgery. She required a high dose of corticosteroids, intravenous immunoglobulins, and rituximab. No further thrombotic events occurred. Rituximab may be an effective treatment option for patients with CAPS.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Catastrophic antiphospholipid syndrome treated with rituximab: A case report
dc.type info:eu-repo/semantics/article


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