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Chiral 1,4-Hydroxyarylalcohols (HAROLs) and 1,4-Aminoalkylphenols (AAPs) as Organocatalysts for Asymmetric Hetero Diels-Alder Reaction

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dc.creator Tilki, Tahir
dc.creator Tezeren, Mustafa Ali
dc.creator Ertürk, Erkan
dc.date 2019-10-31T21:00:00Z
dc.date.accessioned 2020-10-26T13:12:13Z
dc.date.available 2020-10-26T13:12:13Z
dc.identifier 019dec84-bb03-4877-aba1-f94575298b1e
dc.identifier 10.29233/sdufeffd.649920
dc.identifier https://avesis.sdu.edu.tr/publication/details/019dec84-bb03-4877-aba1-f94575298b1e/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/77348
dc.description <p>In this study, two chiral 2-(2-hydroxyaryl) alcohols (HAROLs; 1,4-diols) and a 1,4-aminoalkylphenol (AAP) were examined as hydrogen-bond donor (HBD) organocatalysts in theasymmetric hetero Diels-Alder (HDA) reaction of aldehydes with Rawal’s diene. Catalyticamount (10 mol%) of the both scaffolds (HAROL and AAP) have been found to effect the HDAreaction in a quite efficient manner. Among them, a HAROL molecule based on indan backbonewas turned out to be the best in terms of catalytic activity and enantioselectivity. On the otherhand, AAP tested seemed to act as a bifunctional organocatalyst, i.e. as both a Lewis base andHBD organocatalyst. Experimental results underpins that a careful tuning of HAROL structuremight lead to the development of more general HBD organocatalysts.&nbsp;<br></p>
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Chiral 1,4-Hydroxyarylalcohols (HAROLs) and 1,4-Aminoalkylphenols (AAPs) as Organocatalysts for Asymmetric Hetero Diels-Alder Reaction
dc.type info:eu-repo/semantics/article


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