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Comparison of Serum VEGF, IGF-1, and HIF-1 alpha Levels in Children with Autism Spectrum Disorder and Healthy Controls

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dc.creator Kılıç, Faruk
dc.creator Şirin, Fevziye Burcu
dc.creator Şimşek, Fulya
dc.creator Bozkurt, Mustafa
dc.creator Işık, Ümit
dc.creator Aktepe, Evrim
dc.date 2021-10-01T00:00:00Z
dc.identifier 678bc9d0-d634-4e1a-bc4c-bb437f5815c0
dc.identifier 10.1007/s10803-020-04820-w
dc.identifier https://avesis.sdu.edu.tr/publication/details/678bc9d0-d634-4e1a-bc4c-bb437f5815c0/oai
dc.description The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1 alpha levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1 alpha were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1 alpha levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1 alpha may play a potential role in the etiopathogenesis of ASD.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Comparison of Serum VEGF, IGF-1, and HIF-1 alpha Levels in Children with Autism Spectrum Disorder and Healthy Controls
dc.type info:eu-repo/semantics/article


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