| dc.creator |
Koylu, H |
|
| dc.creator |
Yonden, Z |
|
| dc.creator |
Altuntas, I |
|
| dc.creator |
Delibas, N |
|
| dc.creator |
Sutcu, R |
|
| dc.date |
2004-10-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:15:23Z |
|
| dc.date.available |
2021-12-03T11:15:23Z |
|
| dc.identifier |
134035c2-f313-4f8d-a082-054b2012290d |
|
| dc.identifier |
10.1080/00207450490476147 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/134035c2-f313-4f8d-a082-054b2012290d/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/90046 |
|
| dc.description |
This study examined the effects of streptozotocin (STZ)-diabetes and dietary long chain polyunsaturated fatty acids (LC-PUFAs) on hippocampal N-methyl-D-aspartate (NMDA) receptor subunit expression and lipid peroxidation. MDA level was significantly increased after 8 weeks of STZ-diabetes. LC-PUFAs administration significantly reduced MDA levels in diabetic rats. NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats. Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats. Consequently, dietary LC-PUFAs can partially restore hippocampal NMDA receptors and decrease lipid peroxidation in diabetes. LC-PUFAs arc thus a possible prophylactic means for preventing the cognitive deficiencies of diabetes. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Effects of dietary long chain PUFAs on hippocampal lipid peroxidation and NMDA receptor subunits A and B concentration in streptozotocin-diabetic rats |
|
| dc.type |
info:eu-repo/semantics/article |
|