| dc.creator |
Ergin, Volkan |
|
| dc.creator |
Ozatik, Orhan |
|
| dc.creator |
DÜNDAR, YASEMİN |
|
| dc.creator |
ÖNKOL, TİJEN |
|
| dc.creator |
Ozatik, Yasemin |
|
| dc.creator |
Sahin, M. Fethi |
|
| dc.creator |
EROL, Kevser |
|
| dc.creator |
Menevse, Adnan |
|
| dc.date |
2012-05-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:15:24Z |
|
| dc.date.available |
2021-12-03T11:15:24Z |
|
| dc.identifier |
13c79a7a-4ab7-4253-9581-77de7329a989 |
|
| dc.identifier |
10.2174/1573406411208030481 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/13c79a7a-4ab7-4253-9581-77de7329a989/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/90056 |
|
| dc.description |
Alkylphenols have xenoestrogenic activity, which mimic the action of physiological estrogens and these mim-icking activities are mainly mediated by nongenomic pathway. Nongenomic pathway plays a pivotal role in breast, endometrial and ovarian cancers' growth and development. In this study, various alkylphenol derivatives were prepared and screened for their anti-uterotrophic and uterotrophic activity. Among these compounds, 2-hydroxy-5-nonanoylbenzamide (compound 1b) showed 93.99% inhibitory activity in the anti-uterotrophic test performed, and was found inactive in the uterotrophic activity test. Moreover, all test compounds were examined for the effect on uterine histopathological changes, and plasma 17 beta-estradiol (E-2) level. Compound 1b was also tested for in vitro anti-cancer activity against ER+, human breast cancer cell line MCF-7, and it reduced cell viability to 74.01% at 50 nM concentration. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Synthesis and Biological Evaluation of the Salicylamide and Salicylic Acid Derivatives as Anti-Estrogen Agents |
|
| dc.type |
info:eu-repo/semantics/article |
|