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The Questionable Diverse Effect of Agomelatine On Cisplatin Keratotoxicity

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dc.creator Karaca, Umut
dc.date 2021-04-28T00:00:00Z
dc.date.accessioned 2021-12-03T11:15:35Z
dc.date.available 2021-12-03T11:15:35Z
dc.identifier 16b159bc-c8fc-4f84-96eb-3e3c4542c2ea
dc.identifier https://avesis.sdu.edu.tr/publication/details/16b159bc-c8fc-4f84-96eb-3e3c4542c2ea/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/90117
dc.description <p>Objectives: The high blood flow and rapid metabolic activity of the retina and choroid are themain reasons why the eye is susceptible to toxic effects under cisplatin therapy. Therefore, it isnecessary to investigate and uncover possible mechanisms to find ways to prevent the toxiceffect. The present study aimed to investigate the effects of agomelatine on cisplatin-inducedkeratotoxicity by histopathological analyzes. Methods: Animals were administered withcisplatin (7 mg/kg, i.p.) and treated with agomelatine (20 and 40 mg/kg, p.o) for seven days. Histopathological analysis was performed to determined structural changes in corneal tissue. Inhistopathological examination performed with 40x objective; corneal epithelial irregularity andhyperplasia were evaluated under the headings of corneal, stromal inflammatory infiltration,and stromal edema, and histopathological scoring were performed. Key findings:Histopathological analysis was performed to observe and evaluate the effects of agomelatineon the cornea. Corneal epithelial thickness was naturally observed in the sections belonging tothe control group. Corneal stroma was also observed in natural appearance; there were no signsof stromal inflammatory infiltration or edema. Signs of irregularity and hyperplasia in thecorneal epithelium were observed in sections belonging to the cisplatin group. Inflammatorycell infiltration and edema in some areas were observed in the corneal stroma. A decrease inhistopathological findings was observed in the cisplatin + agomelatine 20 mg/kg groupcompared to the cisplatin group. In the cisplatin + agomelatine 40 mg/kg group, there was adecrease in stromal edema compared to the cisplatin group, but no significant reduction in otherhistopathological findings. Conclusions: Our results provide evidence for the possibleprotective action of agomelatine in cisplatin treatment. Hence, it is clear that our results needto be investigated in more detail for the responsible mechanism underlying this discrepancy.<br></p>
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title The Questionable Diverse Effect of Agomelatine On Cisplatin Keratotoxicity
dc.type info:eu-repo/semantics/conferenceObject

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