| dc.creator |
Ceylan, B. G. |
|
| dc.creator |
Kutuk, S. |
|
| dc.creator |
Aynali, A. |
|
| dc.creator |
Aynali, G. |
|
| dc.creator |
Yavuz, L. |
|
| dc.creator |
Alaca, A. |
|
| dc.date |
2012-05-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:15:43Z |
|
| dc.date.available |
2021-12-03T11:15:43Z |
|
| dc.identifier |
18ddf1b4-3293-4c88-ac3e-ef4249a73194 |
|
| dc.identifier |
10.1177/147323001204000337 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/18ddf1b4-3293-4c88-ac3e-ef4249a73194/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/90178 |
|
| dc.description |
OBJECTIVE: To determine the effect of immunoglobulin (Ig)M-enriched Ig therapy on mortality rate and renal function in sepsis-induced multiple organ dysfunction syndrome (MODS), using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. METHODS: Retrospective study of patients with sepsis-induced MODS treated with standard antibiotic plus supportive therapy (control group) or IgM-enriched Ig therapy adjuvant to control group therapy (IVIg group). Total length of stay in the intensive care unit (ICU), overall mortality rate and 28-day case fatality rate (CFR), as well as APACHE II scores and renal function parameters at day 1 and day 4 of therapy, were recorded. RESULTS: A total of 118 patients were included (control group, n = 62; IVIg group, n = 56). In both groups, day 4 APACHE II scores decreased significantly compared with day 1 scores; the effect of treatment on renal function was minimal. Length of ICU stay, overall mortality rate and 28-day CFR were significantly lower in the IVIg group compared with the control group. CONCLUSIONS: Adding IgM-enriched Ig therapy to standard therapy for MODS improved general clinical conditions and significantly reduced APACHE II scores, overall mortality rate and 28-day CFR, although effects on renal function were minimal. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.title |
The Effects of Adjuvant Immunoglobulin M-enriched Immunoglobulin Therapy on Mortality Rate and Renal Function in Sepsis-induced Multiple Organ Dysfunction Syndrome: Retrospective Analysis of Intensive Care Unit Patients |
|
| dc.type |
info:eu-repo/semantics/article |
|