| dc.creator |
Yildiz, Sevda Elis |
|
| dc.creator |
Erol, Azize Yasemin Goksu |
|
| dc.creator |
Nazli, Mumtaz |
|
| dc.date |
2012-06-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:16:05Z |
|
| dc.date.available |
2021-12-03T11:16:05Z |
|
| dc.identifier |
1f4409e2-0a95-432d-a6bc-bf1888335e5a |
|
| dc.identifier |
10.3109/14767058.2011.595853 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/1f4409e2-0a95-432d-a6bc-bf1888335e5a/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/90327 |
|
| dc.description |
Objective: Although preeclampsia (PE) is one of the most important problems affecting pregnant women, etiologic factors in its development are still unclear. We aimed to investigate the expression levels of cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha) and inducible NO synthase (iNOS) in preeclamptic and healthy control placentas. Patients and methods: Placental tissue samples were obtained after delivery from patients diagnosed with PE and from normal-term pregnants and analyzed for COX-2, TNF-alpha and iNOS expression by immunohistochemistry. Results: A strong expression of COX-2 was observed in syncytiotrophoblast cells of preeclamptic placentas, which was significantly higher than that of normal placentas (p = 0.005). A mild expression of TNF-alpha in both normal and preeclamptic syncytiotrophoblasts was seen (p = 0.435). In addition, a strong expression of iNOS in normal syncytiotrophoblasts was found, but the intensity of the iNOS expression was highly reduced in preeclamptic placentas (p = 0.001). No correlation was detected between COX-2, TNF-alpha and iNOS expression levels. Conclusion: The findings of a decrease of iNOS expression and an increase of COX-2 expression in placenta suggest the existence of functional roles of iNOS and COX-2 in the pathophysiology of PE, probably by contributing to the reduced placental blood flow and increased resistance to flow in the fetomaternal circulation. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Expression levels of cyclooxygenase-2, tumor necrosis factor-alpha and inducible NO synthase in placental tissue of normal and preeclamptic pregnancies |
|
| dc.type |
info:eu-repo/semantics/article |
|