| dc.creator |
Koc, Umran |
|
| dc.creator |
ULUSOY, Seyhan |
|
| dc.creator |
Oksuz, Lutfi |
|
| dc.creator |
Uygun, Emre |
|
| dc.creator |
BİNGÖL ÖZAKPINAR, ÖZLEM |
|
| dc.creator |
KURALAY, FİLİZ |
|
| dc.creator |
Yurdabak Karaca, Gozde |
|
| dc.creator |
Uygun Oksuz, Aysegul |
|
| dc.creator |
Bosgelmez Tinaz, Gulgun |
|
| dc.date |
2023-01-01T00:00:00Z |
|
| dc.identifier |
23945efc-0c78-49ce-b46c-53706fff73c7 |
|
| dc.identifier |
10.1007/s13204-021-01735-5 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/23945efc-0c78-49ce-b46c-53706fff73c7/oai |
|
| dc.description |
The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Catalytic Au/PEDOT/Pt micromotors for cancer biomarker detection and potential breast cancer treatment |
|
| dc.type |
info:eu-repo/semantics/article |
|