| dc.creator |
Gergerlioglu, S |
|
| dc.creator |
Sogut, S |
|
| dc.creator |
Iraz, M |
|
| dc.creator |
Yagmurca, M |
|
| dc.creator |
Yilmaz, HR |
|
| dc.creator |
Kotuk, M |
|
| dc.creator |
Yildirim, Z |
|
| dc.creator |
Ozyurt, H |
|
| dc.date |
2004-07-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:19:35Z |
|
| dc.date.available |
2021-12-03T11:19:35Z |
|
| dc.identifier |
2e4c4e11-f128-48a4-93d7-52f08a97d8fc |
|
| dc.identifier |
10.1002/jat.983 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/2e4c4e11-f128-48a4-93d7-52f08a97d8fc/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/90674 |
|
| dc.description |
The aim of this study was to investigate the optimum dosage of erdosteine to ameliorate cisplatin-induced nephrotoxicity. Three different doses of erdosteine at 25, 50 and 75 mg kg(-1) were studied in rats. Intraperitoneal administration of 7 mg kg(-1) cisplatin led to acute renal failure, as indicated by kidney histology and increases in plasma creatinine and blood urea nitrogen (BUN) levels. At 5 days after cisplatin injection the BUN level was increased significantly from 15.1 +/- 4.3 to 126.7 +/- 152.6 mg dl(-1) and plasma creatinine levels increased from 0.37 +/- 0.005 to 1.68 +/- 1.9 mg dl(-1). When the rats were administered 50 and 75 mg kg(-1) erdosteine 24 h before cisplatin injection that was continued until sacrifice (total of 6 days), the BUN and creatinine levels remained similar to control levels and the grade of histology was similar. Erdosteine at doses of 50 and 75 mg kg(-1) ameliorates cisplatin-induced renal failure. The optimum dose of erdosteine may be 50 mg kg(-1) in this study. Copyright 2004 John Wiley Sons, Ltd. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Cisplatin-induced acute renal failure is ameliorated by erdosteine in a dose-dependent manner |
|
| dc.type |
info:eu-repo/semantics/article |
|