| dc.creator |
Ozer, M. K. |
|
| dc.creator |
Delibas, N. |
|
| dc.creator |
Cicek, E. |
|
| dc.creator |
Sutcu, R. |
|
| dc.creator |
Kara, H. Y. |
|
| dc.creator |
Demirin, H. |
|
| dc.creator |
Dogan, M. |
|
| dc.creator |
Donmez, S. |
|
| dc.creator |
Ozdem, S. |
|
| dc.creator |
Gokalp, O. |
|
| dc.date |
2009-08-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:19:52Z |
|
| dc.date.available |
2021-12-03T11:19:52Z |
|
| dc.identifier |
334b0343-321e-4ee5-a854-df8ab0cb0a58 |
|
| dc.identifier |
10.1177/0748233709106822 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/334b0343-321e-4ee5-a854-df8ab0cb0a58/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/90801 |
|
| dc.description |
Abnormalities in the production and/or release of relaxing factors from the endothelium have been implicated in the development of hypertension in several animal models. Endothelium-dependent relaxation has been reported to be impaired in thoracic aorta in experimentally induced and genetically hypertensive rats. Present study has extented these observations to thoracic aorta of cadmium-hypertensive rats. The possible role of alterations in oxidant status was also studied. Hypertension was induced by the intraperitoneal administration of 1 mg/kg/day cadmium for 15 days. Mechanical responses produced by acetylcholine (ACh, 10(-9)-10(-4) M) and sodium nitroprusside (SNP, 10(-10)-10(-5) M) were studied on phenylephrine-precontracted thoracic aorta rings from control and cadmium-hypertensive rats. Serum nitric oxide (NO) and aortic malondialdehyde (MDA) levels were measured. ACh-induced relaxation was attenuated in aorta from cadmium-hypertensive rats, whereas relaxation responses to SNP did not differ significantly between the groups. Exposure of aortic rings to N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) resulted in a significantly greater inhibition of relaxation response to ACh in aortic rings of cadmium-hypertensive rats as compared with control rats. Incubation with L-arginine (L-Arg, 10(-3) M) caused a similar reversal of the inhibition of ACh-induced relaxation by L-NAME in both groups. Serum NO levels were decreased and aortic MDA levels were increased in cadmium-treated rats as compared with control rats. However, the differences between the groups did not reach a statistical significance. These findings suggested that the reduction in endothelium-dependent relaxation may play a role in cadmium-induced hypertension as it was in many other hypertension models. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Impairment of endothelium-dependent vasorelaxation in cadmium-hypertensive rats |
|
| dc.type |
info:eu-repo/semantics/article |
|