| dc.creator |
Naziroglu, M. |
|
| dc.date |
2006-01-01T01:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:29:41Z |
|
| dc.date.available |
2021-12-03T11:29:41Z |
|
| dc.identifier |
64067065-9460-418d-9815-2b8a28e50258 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/64067065-9460-418d-9815-2b8a28e50258/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/92242 |
|
| dc.description |
We tested the effects of various antioxidants on H2O2- induced TRPM2 cation channel currents. CHO cells were transfected with cDNA coding for TRPM2. The antioxidants glutathione, vitamins C and E were applied either extracellularly or intracellularly. Non-selective cation currents in whole cell experiments were consistently induced by intracellular ADP- ribose, NAD and extracellular H2O2. ADP-ribose and NAD was characterized a slow current induction to a plateau although the inward currents of H2O2 administration did not reach a plateau after even 15-20 min. No intracellular antioxidants prevented the H2O2- induced current development in whole and single-channel activities of the cells. We concluded that non reversible the selective cation channel currents induced by H2O2 although the antioxidants have no effects on the activation. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Non reversible activation of TRPM2 cation channels by hydrogen peroxide: Antioxidants haven't inbitor rule on the activation |
|
| dc.type |
info:eu-repo/semantics/conferenceObject |
|