| dc.creator |
Cinar, K. |
|
| dc.creator |
Oztop, M. |
|
| dc.creator |
Turk, S. |
|
| dc.date |
2019-12-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:30:00Z |
|
| dc.date.available |
2021-12-03T11:30:00Z |
|
| dc.identifier |
699bb877-fffc-4f37-9a57-4720d4bd0c3e |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/699bb877-fffc-4f37-9a57-4720d4bd0c3e/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/92360 |
|
| dc.description |
Background: Gastrointestinal (GI) endocrine cells produce many GI hormones that perform various physiological functions of the digestive system. Aims: We aimed to investigate the presence and distribution of immunoreactive (IR) endocrine cells to glucagon, somatostatin, cholecystokinin-8 (CCK-8), serotonin, secretin and histamine in the stomach of adult male New Zealand White rabbit (Oryctolagus cuniculus). Methods: For immunohistochemical staining, peroxidase anti-peroxidase (PAP) method was applied to stomach samples. Results: Glucagon-IR cells of closed- and open type were found throughout all the stomach parts examined. Somatostatin-IR cells of closed- and open type in the cardiac and oxyntic glands were localized to deep portions of foveola gastrica. CCK-8 IR cells that were not observed in the cardia and fundus were mostly localized to the glands and lamina epithelialis in the pyloric part near the duodenum. Oval-shaped open and closed type serotonin-IR cells were mostly dispersed throughout the fundic and pyloric glands. Secretin-IR cells were rare in the pyloric and cardiac region although they were not observed in the fundic glands. Histamine-IR cells were rarely found in the cardia, fundus and pylorus. Conclusion: Our findings show that glucagon, histamine, somatostatin, secretin and serotonin might be produced by all the stomach regions while pyloric region had only CCK-8 IR. These distribution patterns also provide further evidence of species-specific differences, which might be important from the evolutionary aspect of the digestive tract in relation to evolutional niches and nutrient resources. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Distribution and relative frequency of immunohistochemically detected endocrine cells in the stomach of New Zealand White rabbit (Oryctolagus cuniculus) |
|
| dc.type |
info:eu-repo/semantics/article |
|