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nm23 protein expression of choroidal melanoma was investigated to determine its relationship with clinical and histopathological characteristics of the tumour, Thirty-four consecutive choroidal melanoma patients were examined by immunohistochemistry. Although age, sex, tumour cell type, tumour size, pigmentation, necrosis, apoptosis and tumour lymphocytic infiltration were not correlated with nm23 protein expression, tumours with low percentages of nm23-positive cells revealed higher nuclear grades and predominant mitotic figures, nm23 may be associated with melanoma progression, but there is no proof that it plays a role in the metabolic process of the tumour, Copyright (C) 2000 S. Karger AG, Basel. |
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