| dc.creator |
ÇELİK, AYGÜL |
|
| dc.creator |
Agalar, Canan |
|
| dc.creator |
Karabay, Oguz |
|
| dc.creator |
Batirel, Ayse |
|
| dc.creator |
Balkan, Ilker Inanc |
|
| dc.creator |
AKALIN, ŞERİFE |
|
| dc.creator |
Alici, Ozlem |
|
| dc.creator |
Yilmaz, Hava |
|
| dc.creator |
Turker, Nesrin |
|
| dc.creator |
Turhan, Vedat |
|
| dc.creator |
Sezak, Nurbanu |
|
| dc.creator |
Oztoprak, Nefise |
|
| dc.creator |
Ozer, Serdar |
|
| dc.creator |
ÖZDEMİR, DAVUT |
|
| dc.creator |
Ormen, Bahar |
|
| dc.creator |
Kilic, Aysegul Ulu |
|
| dc.creator |
Karahocagil, Mustafa Kasim |
|
| dc.creator |
Hosoglu, Salih |
|
| dc.creator |
Hatipogiu, Cigdem Ataman |
|
| dc.creator |
Guven, Tumer |
|
| dc.creator |
Guciu, Ertugrul |
|
| dc.creator |
Gonen, Ibak |
|
| dc.creator |
Engin, Derya Ozturk |
|
| dc.creator |
ENGİN, AYNUR |
|
| dc.creator |
Duygu, Fazilet |
|
| dc.creator |
Durdu, Bulent |
|
| dc.creator |
DOĞAN, MUSTAFA |
|
| dc.creator |
Cesur, Salih |
|
| dc.creator |
Bekiroglu, Nural |
|
| dc.creator |
Aslan, Turan |
|
| dc.creator |
Arslan, Ferhat |
|
| dc.creator |
Altin, Nilgun |
|
| dc.creator |
Altay, Fatma Aybala |
|
| dc.creator |
Alp, Emine |
|
| dc.date |
2015-01-01T01:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:30:04Z |
|
| dc.date.available |
2021-12-03T11:30:04Z |
|
| dc.identifier |
6abe6b06-5994-4c66-8145-45ccefe60ed7 |
|
| dc.identifier |
10.4103/0253-7613.150383 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/6abe6b06-5994-4c66-8145-45ccefe60ed7/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/92379 |
|
| dc.description |
Objectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis |
|
| dc.type |
info:eu-repo/semantics/article |
|