| dc.creator |
Tunc, M |
|
| dc.creator |
Altuntas, I |
|
| dc.creator |
Ozdemir, T |
|
| dc.creator |
Kaya, M |
|
| dc.date |
2003-05-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:30:16Z |
|
| dc.date.available |
2021-12-03T11:30:16Z |
|
| dc.identifier |
6e75b55e-65fe-4514-9e7b-59377cccab75 |
|
| dc.identifier |
10.1007/s00417-002-0610-8 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/6e75b55e-65fe-4514-9e7b-59377cccab75/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/92451 |
|
| dc.description |
Purpose: To detect the neuroprotective role of nimodipine and dantrolene in N-methyl-D-aspartate (NMDA)-induced retinal injury. Methods: In this study we used two calcium antagonists which have two different modes of action, nimodipine and dantrolene, to prevent NMDA-induced retinal ischemia in guinea pigs. In 40 animals we injected nimodipine (n=10), dantrolene (n=10), a combination of both (n=10) or sterile 0.9% NaCl solution as a placebo (n=10) before intravitreal injection of NMDA. We enucleated one eye of each animal after 48 hours and performed histopathologic examination. We also measured malondialdehyde (MDA) levels in retinal homogenates as a marker of ischemic injury. Results: Our results indicate that ganglion cells of the retina were preserved mostly by nimodipine, followed by combined nimodipine-dantrolene, and dantrolene respectively. The ganglion cell count was statistically significantly higher in cases where we used calcium antagonists than in the control group (p<0.05). We also found that MDA was significantly reduced by calcium antagonists compared to the control group (p<0.05). Conclusion: Our data show that nimodipine and dantrolene both have potential neuroprotective effects; nimodipine preserved retinal ganglion cells to a greater extent than dantrolene from NMDA-induced retinal injury. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Calcium antagonists in N-methyl D-aspartate-induced retinal injury |
|
| dc.type |
info:eu-repo/semantics/article |
|