| dc.creator |
Oner, AF |
|
| dc.creator |
Hicsonmez, G |
|
| dc.creator |
Tunc, B |
|
| dc.date |
2002-01-01T01:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:30:41Z |
|
| dc.date.available |
2021-12-03T11:30:41Z |
|
| dc.identifier |
75ac396d-6f29-47f6-9c1c-2ca848924a0f |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/75ac396d-6f29-47f6-9c1c-2ca848924a0f/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/92651 |
|
| dc.description |
This study was undertaken to determine the effect of short-course high-dose methylprednisolone (HDMP) treatment on peripheral blood (PB) CD34(+) progenitor cells during remission induction treatment in 11 children with newly diagnosed acute leukemia (7 with ALL, 4 with AML) whose bone marrow (BM) cells expressed fewer than 5% CD34 at the time of diagnosis. All children who had no infection were given HDMP as a single daily oral dose of 30 mg/kg for the first four days of induction therapy. The number of CD34(+) progenitor cells were determined by flow cytometry before and after four days of HDMP treatment. While the number of PB blast cells significantly decreased after only a four-day course of HDMP treatment, the number of PB CD34(+) progenitor cells increased in all patients. In addition, after four days of HDMP treatment polymorphonuclear leukocytes (PMN) and mononuclear cells (MNC) increased significantly (p < 0.05). We suggest that the potential beneficial effects of HDMP in the induction treatment of acute leukemia may occur partly by the stimulation of PB CD34(+) hematopoietic progenitor cells in a short period of time. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
The effect of short-course high-dose methylprednisolone on peripheral blood CD34(+) progenitor cells of children with acute leukemia during remission induction therapy |
|
| dc.type |
info:eu-repo/semantics/article |
|