| dc.creator |
Himmetoglu, O |
|
| dc.creator |
Erdem, A |
|
| dc.creator |
Erdem, M |
|
| dc.creator |
Yildirim, G |
|
| dc.creator |
Arslan, M |
|
| dc.date |
2003-01-01T01:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:31:48Z |
|
| dc.date.available |
2021-12-03T11:31:48Z |
|
| dc.identifier |
8a1efd26-f08b-49fc-bf19-c0f81a529215 |
|
| dc.identifier |
10.1515/jpm.2003.008 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/8a1efd26-f08b-49fc-bf19-c0f81a529215/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/93186 |
|
| dc.description |
The objective of this study was to examine maternal and fetal endothelin-1 (ET-1) in pregnancies complicated with intrauterine growth restriction (IUGR) and to correlate these data with umbilical artery Doppler flow velocity waveforms (FVW). Higher mean maternal (13.8 +/- 6,4 vs 9.2 +/- 3,4 pmol/L, p < 0.05) and fetal (18.5 +/- 9.6 vs 11.7 +/- 6.9 pmol/L,p < 0.05) ET-1 levels were found in pregnancies complicated with IUGR than in controls. Fetal ET- level was related to birth weight percentile for gestational week. Maternal and fetal ET-1 concentrations were not related to umbilical artery Doppler flow S/D ratio, PI and RI. Maternal or fetal ETI concentrations were also not related to umbilical artery pH, pO(2) and pCO(2). Pregnancy-induced hyperten-sion was significantly associated with an elevated fetal and maternal ET-1 concentration. In conclusion, increased production and secretion of ET-I may play a role in the pathophysiology of idiopathic IUGR. Over-production of ET-1 in IUGR is not associated with increased placental resistance as reflected in abnormal umbilical artery Doppler FVW. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Maternal and fetal plasma endothelin levels in intrauterine growth restriction: relation to umbilical artery Doppler flow velocimetry |
|
| dc.type |
info:eu-repo/semantics/article |
|