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ZEYTİN YAPRAĞI POLİFENOLLERİ YÜKLÜ MUKOADHESİF ORAL FİLMLER

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dc.creator KÖSE, Merve Deniz; EGE UNIVERSITY
dc.creator GÜMÜŞ IŞIK, Şeyma; EGE UNIVERSITY
dc.creator BAYRAKTAR, Oguz; EGE UNIVERSITY
dc.date 2021-06-20T00:00:00Z
dc.date.accessioned 2021-12-03T11:45:37Z
dc.date.available 2021-12-03T11:45:37Z
dc.identifier https://dergipark.org.tr/tr/pub/jesd/issue/62893/866532
dc.identifier 10.21923/jesd.866532
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/93684
dc.description İlaç aktarım sistemleri arasında, ağızda çözünen filmler (AÇF'ler) birçok avantajı olan bir ilaç uygulama şeklidir. Yutma gerektiren geleneksel ilaç verme yöntemleri ile özellikle pediatrik ve geriatrik hastalarda bazı sorunlar yaşanabilir. Bu gibi durumlarda, ilacın ağızda dağılmış bir filmle verilmesi büyük kolaylık sağlar. Bu çalışmada, filmlerin hazırlanması için solvent döküm yöntemi tercih edilmiştir. Biyopolimer oranı ve yüklenmiş zeytin yaprağı ekstraktının film özellikleri üzerindeki etkisi, merkezi kompozit deneysel tasarım ile araştırılmıştır. Hazırlanan filmlerin karakterizasyon çalışmaları AFM, SEM ve FTIR analizleri ile yapılmıştır. Karakterizasyon çalışmalarına dayanarak, en iyi dört formülasyon seçilmiş ve araştırmada bu formülasyonlara odaklanılmıştır. Formülasyon 8, esneklik ve homojenlik gibi daha iyi film özellikleri, daha düşük parçalanma süresi (200 s) ve daha yüksek antioksidan kapasitesi (3.21 mM TEAC/g AÇF) nedeniyle 17 formülasyon arasından optimum formülasyon olarak seçilmiştir. Elde edilen veriler, hazırlanan ağızda çözünen filmlerle zeytin yaprağı polifenollerinin aktarımının mümkün olduğunu ortaya koymuştur.
dc.description Among drug delivery systems, mouth dissolving films (MDFs) are a form of drug administration with many advantages. Some problems could be experienced, primarily in pediatric and geriatric patients with conventional drug delivery methods as swallowing. It is of great convenience to dispensing the drug with a film dispersed in the mouth in such cases. In this study, for the preparation of films, the solvent casting method was preferred. The effect of biopolymer ratio and loaded olive leaf extract on the film properties were investigated with the central composite experimental design. Characterization studies of the prepared films were done with AFM, SEM, and FTIR analysis. Based on the characterization studies, the four best formulations were chosen, and further investigations were focused on these formulations. Formulation 8 was chosen as the optimum formulation among 17 formulations due to its better film properties as flexibility and homogeneity, lower disintegration time 200s, and a higher antioxidant capacity 3.21 mM TEAC/g MDF. The obtained data revealed that it is possible to deliver olive leaf polyphenols with the prepared mouth dissolving films.
dc.format application/pdf
dc.language en
dc.publisher Süleyman Demirel Üniversitesi
dc.publisher Süleyman Demirel University
dc.relation https://dergipark.org.tr/tr/download/article-file/1527098
dc.source Volume: 9, Issue: 2 366-380 en-US
dc.source 1308-6693
dc.source Mühendislik Bilimleri ve Tasarım Dergisi
dc.subject Ağızda Çözünen Film,Oral Film,Karboksimetil Kitosan,Bamya Zamkı,Zeytin Yaprağı Ekstraktı
dc.subject Mouth Dissolving Film,Oral Film,Carboxymethyl Chitosan,Okra Gum,Olive Leaf Extract
dc.title ZEYTİN YAPRAĞI POLİFENOLLERİ YÜKLÜ MUKOADHESİF ORAL FİLMLER tr-TR
dc.title OLIVE LEAF POLYPHENOLS LOADED MUCOADHESIVE ORAL FILMS en-US
dc.type info:eu-repo/semantics/article
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