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Side Effect of Dual Effect: Hyperprolactinemia and Galactorrhea Case

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dc.creator TANRITANIR, Bilal; BUCAK DEVLET HASTANESİ
dc.creator GÜNDOĞAN, Meltem; Eskişehir Yunus Emre Devlet Hastanesi
dc.date 2021-04-30T00:00:00Z
dc.date.accessioned 2021-12-03T11:46:24Z
dc.date.available 2021-12-03T11:46:24Z
dc.identifier https://dergipark.org.tr/tr/pub/sdusbed/issue/61847/799217
dc.identifier 10.22312/sdusbed.799217
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/93868
dc.description Objective: Venlafaxine is an antidepressant with serotonin, noradrenaline (NE) and dopamine reuptake inhibitor properties. Hyperprolactinemia and galactorrhea, which can occur with venlafaxine use, are rare conditions and have been reported with case reports. With this case, it was aimed not to ignore galactorrhea and increased prolactin, which are one of the rare side effects of antidepressants, which are among the most frequently used treatment agents in psychiatric treatment approaches, and to realize that these side effects do not occur solely due to the use of antipsychotics. Case: A 41-year-old female patient, who had depressive complaints for about 6 years and did not reach complete remission, had hyperprolactinemia and galactorrhea side effects after treatment. Conclusion: In addition to the serotonergic, noradrenergic and dopaminergic effects of venlafaxine in a dose-dependent manner, its side effects are also dose-dependent. It has been argued that noradrenergic factors may also be effective in addition to serotonergic and dopaminergic factors in the etiology of galactorrhea with hyperprolactinemia.
dc.description Amaç: Venlafaksin doz bağımlı olarak serotonin, noradrenalin(NA) ve dopamin gerialım inhibitörü özellikleri gösteren bir antidepresandır. Venlafaksin kullanımı ile ortaya çıkabilen hiperprolaktinemi ve galaktore nadir görülen bir durum olup olgu sunumları ile bildirilmiştir. Bu olgu ile psikiyatrik tedavi yaklaşımlarında en sık kullanılan tedavi ajanlarından olan antidepresanların nadir görülen yan etkilerinden biri olan galaktore ve prolaktin artışının klinisyenler tarafından göz ardı edilmemesi ve bu yan etkilerin sadece antipsikotik kullanımına bağlı olarak ortaya çıkmadığının farkına varılması hedeflenmiştir.Olgu: Yaklaşık 6 yıldır depresif şikayetleri olan ve tam remisyona ulaşmayan 41 yaşındaki kadın hastanın tedavisinin düzenlenmesi sonrasında ortaya çıkan hiperprolaktinemi ve galaktore yan etkilerinin olduğu olgu sunulmuştur.Sonuç:Venlafaksinin doz bağımlı olarak ortaya çıkardığı serotonerjik, noradrenerjik ve dopaminerjik etkilerin yanı sıra yan etkilerininde doz bağımlı olarak ortaya çıkmaktadır. Özellikle Hiperprolaktinemiile galaktoreninetyolojisinde yer alan serotonerjik ve dopaminerjik faktörler dışında noradrenerjik faktörlerin de etkili olabileceği tartışılmıştır.
dc.format application/pdf
dc.language tr
dc.publisher Süleyman Demirel Üniversitesi
dc.publisher Süleyman Demirel University
dc.relation https://dergipark.org.tr/tr/download/article-file/1306544
dc.source Volume: 12, Issue: 1 117-119 en-US
dc.source 2146-247X
dc.source Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi
dc.subject venlafaksin,hiperprolaktinemi,galaktore
dc.title Side Effect of Dual Effect: Hyperprolactinemia and Galactorrhea Case en-US
dc.title Dual Etkinin Yan Etkisi: Hiperprolaktinemi ve Galaktore Olgusu tr-TR
dc.type info:eu-repo/semantics/article
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