Monocyte count to high-density lipoprotein cholesterol ratio and mean platelet volume may be related to the severity of carotid artery stenosis.

AYYILDIZ, Veysel  Atilla; Isparta Süleyman Demirel University, Faculty of Medicine, Department of Radiology; KUYUMCU, Mevlüt Serdar; Isparta Süleyman Demirel University, Faculty of Medicine, Department of Cardiology

dc.creator	AYYILDIZ, Veysel Atilla; Isparta Süleyman Demirel University, Faculty of Medicine, Department of Radiology
dc.creator	KUYUMCU, Mevlüt Serdar; Isparta Süleyman Demirel University, Faculty of Medicine, Department of Cardiology
dc.date	2021-04-30T00:00:00Z
dc.date.accessioned	2021-12-03T11:46:26Z
dc.date.available	2021-12-03T11:46:26Z
dc.identifier	https://dergipark.org.tr/tr/pub/sdusbed/issue/61847/831028
dc.identifier	10.22312/sdusbed.831028
dc.identifier.uri	http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/93889
dc.description	Objective: The pathophysiology of carotid artery stenosis (CAD) is not fully understood. Research has showed that mean platelet volume (MPV) is a potential marker for platelet activation and is a key factor in atherosclerosis pathophysiology. Recently, the ratio of monocyte count to HDL (MHR) has been identified as a predictor of cardiovascular events in patients. In the light of these findings, the goal of study was to evaluate the potential association of MPV and MHR with the severity of CAD.Material-Method: Patients had divided into three groups: CAD≥ 60% (40 patients), CAD &lt;60% (40 patients) and no carotid atherosclerotic disease (40 individuals). Patients' demographic characteristics, clinical features and laboratory findings were compared between groups.Results: MPV and MHR leves were lower in the control group than CAD &lt;60 group and lower in CAD &lt;60 group than CAD ≥60 group (p &lt;0.001, p &lt;0.001). Higher MPV (OR= 6.050; 95% CI: 2.946-12.427; p &lt;0.001) and MHR (OR= 1.107; 95% CI: 1.045-1.159; p &lt;0.001) levels were detected as independent predictor for ≥60% carotid artery stenosis after multiple linear regression analysis. In the correlation analysis, a positive correlation was found between MPV and the rate of carotid artery stenosis (p&lt;0.001, r=0.680). Conclusion: In our study, a potential relationship between MPV and MHR with carotid artery disease was determined. Our study may make contributions to understanding the carotid artery atherosclerosis pathophysiology and developing treatments for it.
dc.description	Amaç: Karotis arter darlığının patofizyolojisi tam olarak anlaşılamamıştır. Araştırmalar, ortalama trombosit hacminin (MPV) trombosit aktivasyonu için potansiyel bir belirteç olduğunu ve ateroskleroz patofizyolojisinde anahtar bir faktör olduğunu göstermiştir. Son zamanlarda, monosit sayısının HDL'ye (MHR) oranı, hastalarda kardiyovasküler olayların bir prediktörü olarak tanımlanmıştır. Bu bulgular ışığında çalışmanın amacı, MPV ve MHR'nin CAD şiddeti ile olası ilişkisini araştırmaktır. Materyal-metot: Hastalar üç gruba ayrıldı: CAD≥%60 (40 hasta), CAD&lt;% 60 (40 hasta) ve karotis aterosklerotik hastalığı olmayan (40 kişi). Hastaların demografik özellikleri, klinik özellikleri ve laboratuvar parametreleri gruplar arasında karşılaştırıldı.Bulgular: Kontrol grubunda MPV ve MHR seviyeleri CAD &lt;60 grubuna göre daha düşük, CAD &lt;60 grubunda CAD ≥60 grubuna göre daha düşüktü (p &lt;0,001, p &lt;0,001). Yüksek MPV (OR = 6.050;% 95 CI: 2.946-12.427; p &lt;0.001) ve MHR (OR = 1.107;% 95 CI: 1.045 -1.159; p &lt;0.001) seviyeleri çoklu lineer regresyon analizinden sonra ≥% 60 karotis arter darlığı için bağımsız prediktör olarak tespit edildi. Korelasyon analizinde MPV ile karotis arter darlığı oranı arasında pozitif korelasyon bulundu (p &lt;0,001, r = 0,680). Sonuç: Çalışmamızda MPV ve MHR ile karotis arter hastalığı arasında potansiyel bir ilişki tespit edildi. Çalışmamız, karotis arter ateroskleroz patofizyolojisinin anlaşılmasına ve buna yönelik tedavilerin geliştirilmesine katkı sağlayabilir.
dc.format	application/pdf
dc.language	en
dc.publisher	Süleyman Demirel Üniversitesi
dc.publisher	Süleyman Demirel University
dc.relation	https://dergipark.org.tr/tr/download/article-file/1414229
dc.source	Volume: 12, Issue: 1 52-59	en-US
dc.source	2146-247X
dc.source	Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi
dc.subject	Carotid artery stenosis,mean platelet volume,monocyte-to-high-density lipoprotein cholesterol ratio
dc.subject	Karotis arter darlığı,ortalama trombosit hacmi,monosit-yüksek yoğunluklu lipoprotein oranı
dc.title	Monocyte count to high-density lipoprotein cholesterol ratio and mean platelet volume may be related to the severity of carotid artery stenosis.	en-US
dc.title	Monosit Sayısının Yüksek Yoğunluklu Lipoprotein Kolesteroel Oranı ve Ortalama Trombosit Hacmi, Karotis Arter Stenozunun Ciddiyeti ile İlişkili Olabilir	tr-TR
dc.type	info:eu-repo/semantics/article
dc.citation	1. Atherosclerosis and the role of inflammation. Archives of the Turkish Society of Cardiology. 2009;37(80):1-6.
dc.citation	2. Güleç S. [Global risk and objectives in cardiovascular diseases]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2009;37 Suppl 2:1-10.
dc.citation	3. Başarici I. [Determination of TIMI frame counts and slow coronary flow/ Relationship between the slow coronary flow and carotid artery intima-media thickness]. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology. 2007;7(3):333-4; author reply 4.
dc.citation	4. Aboyans V, Ricco JB, Bartelink MEL, Björck M, Brodmann M, Cohnert T, et al. 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): European heart journal. 2018;39(9):763-816.
dc.citation	5. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2003;9(3):177-90.
dc.citation	6. Yaşar AS, Bilen E, Yüksel IO, Arslantaş U, Karakaş F, Kirbaş O, et al. Association between admission mean platelet volume and coronary patency after thrombolytic therapy for acute myocardial infarction. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2010;38(2):85-9.
dc.citation	7. Gu Lcan AR, Karakaş MS, Akdemir B, Uçar M, Altekin RE, Yılmaz HS. [Relation between mean platelet volume and subclinical atherosclerosis in patients with metabolic syndrome]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2014;42(1):22-8.
dc.citation	8. Yüksel Kalkan G, Gür M, Baykan AO, Uçar H, Elbasan Z, Şahin DY, et al. Mean platelet volume is associated with aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease. Anatol J Cardiol. 2015;15(9):753-8.
dc.citation	9. Nadar SK, Blann AD, Kamath S, Beevers DG, Lip GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Am Coll Cardiol. 2004;44(2):415-22.
dc.citation	10. Korkmaz L, Korkmaz AA, Akyüz AR, Ağaç MT, Acar Z, Kırış A, et al. Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology. 2012;12(1):35-9.
dc.citation	11. Aşkın L, Çetin M, Türkmen S, Taşolar H, Aktürk E. The relationship between monocyte/high-density lipoprotein ratio and Selvester QRS score in patients with STEMI. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2018;46(4):260-7.
dc.citation	12. Tosheska Trajkovska K, Topuzovska S. High-density lipoprotein metabolism and reverse cholesterol transport: strategies for raising HDL cholesterol. Anatol J Cardiol. 2017;18(2):149-54.
dc.citation	13. Onat A. High density lipoprotein cholesterol in coronary artery patients: is it as low as expected? Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology. 2006;6(1):92-3; author reply 3.
dc.citation	14. Biswas SK. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxidative Medicine and Cellular Longevity. 2016;2016:5698931.
dc.citation	15. Kanbay M, Solak Y, Unal HU, Kurt YG, Gok M, Cetinkaya H, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. International urology and nephrology. 2014;46(8):1619-25.
dc.citation	16. Canpolat U, Çetin EH, Cetin S, Aydin S, Akboga MK, Yayla C, et al. Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2016;22(5):476-82.
dc.citation	17. Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. European heart journal. 2016;37(29):2315-81.
dc.citation	18. Ferguson GG, Eliasziw M, Barr HW, Clagett GP, Barnes RW, Wallace MC, et al. The North American Symptomatic Carotid Endarterectomy Trial : surgical results in 1415 patients. Stroke. 1999;30(9):1751-8.
dc.citation	19. Kuyumcu A, Kuyumcu MS. Akdeniz Diyeti ve Karotis Arter Hastalığı Arasındaki İlişki. SDÜ Sağlık Bilimleri Dergisi. 2019;10(2):99-104.
dc.citation	20. Pafili K, Penlioglou T, Mikhailidis DP, Papanas N. Mean platelet volume and coronary artery disease. Current opinion in cardiology. 2019;34(4):390-8.
dc.citation	21. Vivekananthan DP, Patel VB, Moliterno DJ. Glycoprotein IIb/IIIa antagonism and fibrinolytic therapy for acute myocardial infarction. Journal of interventional cardiology. 2002;15(2):131-9.
dc.citation	22. Kristensen SD. The platelet-vessel wall interaction in experimental atherosclerosis and ischaemic heart disease with special reference to thrombopoiesis. Danish medical bulletin. 1992;39(2):110-27.
dc.citation	23. Ihara A, Kawamoto T, Matsumoto K, Shouno S, Hirahara C, Morimoto T, et al. Relationship between platelet indexes and coronary angiographic findings in patients with ischemic heart disease. Pathophysiology of haemostasis and thrombosis. 2006;35(5):376-9.
dc.citation	24. Celebi OO, Canbay A, Celebi S, Sahin D, Aydoğdu S, Diker E. [The effect of admission mean platelet volume on TIMI frame count measured after fibrinolytic therapy in patients with acute ST-segment elevation myocardial infarction]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2009;37(5):307-11.
dc.citation	25. Karakaş MS, Altekin RE, Baktır AO, Küçük M, Cilli A, Yalçınkaya S. Association between mean platelet volume and severity of disease in patients with obstructive sleep apnea syndrome without risk factors for cardiovascular disease. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2013;41(1):14-20.
dc.citation	26. Nurkalem Z, Alper AT, Orhan AL, Zencirci AE, Sari I, Erer B, et al. Mean platelet volume in patients with slow coronary flow and its relationship with clinical presentation. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2008;36(6):363-7.
dc.citation	27. Demirkol S, Balta Ş, Arslan Z, Küçük U, Ünlü M. [Noninvasive markers such as mean platelet volume in clinical practice]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2013;41(6):575.
dc.citation	28. Varol E. Decreased mean platelet volume in Gilbert's syndrome: role of oxidative stress. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2013;24(6):673.
dc.citation	29. Varol E, Akcay S, Icli A, Yucel H, Ozkan E, Erdogan D, et al. Mean platelet volume in patients with prehypertension and hypertension. Clinical hemorheology and microcirculation. 2010;45(1):67-72.
dc.citation	30. Moghadam RH, Shahmohammadi A, Asgari N, Azizi K, Mansour SM, Roozbahani M. Comparison of mean platelet volume levels in coronary artery ectasia and healthy people: systematic review and meta-analysis. Blood research. 2018;53(4):269-75.
dc.citation	31. Tuncel T, Uysal P, Hocaoglu AB, Erge DO, Karaman O, Uzuner N. Change of mean platelet volume values in asthmatic children as an inflammatory marker. Allergologia et immunopathologia. 2012;40(2):104-7.
dc.citation	32. Nicholls SJ, Dusting GJ, Cutri B, Bao S, Drummond GR, Rye KA, et al. Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits. Circulation. 2005;111(12):1543-50.
dc.citation	33. Kunitake ST, Jarvis MR, Hamilton RL, Kane JP. Binding of transition metals by apolipoprotein A-I-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 1992;89(15):6993-7.