| dc.creator |
ERSUNGUR, Ecem; AYDIN ADNAN MENDERES ÜNİVERSİTESİ |
|
| dc.creator |
ŞİRİNYILDIZ, Ferhat; TIP FAKÜLTESİ |
|
| dc.creator |
CESUR, Gökhan; TIP FAKÜLTESİ |
|
| dc.date |
2021-08-20T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:46:27Z |
|
| dc.date.available |
2021-12-03T11:46:27Z |
|
| dc.identifier |
https://dergipark.org.tr/tr/pub/sdusbed/issue/64440/890311 |
|
| dc.identifier |
10.22312/sdusbed.890311 |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/93893 |
|
| dc.description |
Amaç: Akut respiratuar distres sendromu (ARDS) pulmoner veya ekstrapulmoner nedenlerle gelişerek, akciğerlerde ciddi fonksiyon kaybına veya mortaliteye neden olabilen bir klinik sendromdur. Dekspantenol antioksidan ve anti-inflamatuar etkilere sahip önemli bir tedavi edici ajandır. Materyal-Metod: Çalışmada oleik asit kullanılarak oluşturulan akut respiratuar distres modelinde dekspantenol’ün anti-inflamatuvar ve antioksidan özellikleri değerlendirilmiştir. Bu amaç doğrultusunda 50 dişi Wistar-albino rat beş gruba ayrıldı (n: 10). Gruplar Control (C), Oleik asit (O), Dekspantenol+Oleik asit (DO), Dekspantenol+Oleik asit+Despantenol (DOD) ve Oleik asit+Dekspantenol (OD) olarak adlandırıldı. Sıçanlar sakrifiye edildikten sonra serum örneklerindeki interlökin-1α ile Tümör Nekroz Faktör alfa düzeyleri belirlenmiştir. Akciğer dokusunda ise ışık mikroskobu ile histopatolojik inceleme ve malondialdehid doku, glutatyon peroksidaz, katalaz enzim aktivite düzeyleri ölçümleri yapılmıştır. Bulgular: Elde edilen sonuçlar, oleik asit verilerek tedavi uygulanmamış grupta histopatolojik olarak anlamlı düzeyde akut akciğer hasarı tespit edilmiştir. Doku örneklerine yapılan biyokimyasal analizler histopatolojik sonuçları desteklemektedir. Tedavi gruplarından elde edilen sonuçlar, oleik asidin neden olduğu hasarın dekspantenol tedavisi ile birlikte azaldığını göstermektedir. Özellikle oleik asit uygulanan gruplarda meydana gelen MDA düzeylerindeki artış ve tedavi gruplarında ki azalma ile antioksidan parametrelerdeki artış, oksidatif hasarın etkisini göstermektedir.Sonuçlar: Sonuç olarak dekspantenol uygulamasının deneysel akut respiratuar distres sendromu gelişimini önlemede etkili olduğu, bu etkinin dekspantenolun anti-inflamatuvar ve antioksidan özellikleri sayesinde olduğunu düşünülmektedir. |
|
| dc.description |
Objective: Acute respiratory distress syndrome (ARDS) is a clinical syndrome that can develop due to pulmonary or extrapulmonary causes, causing serious loss of function or mortality in the lungs. Dexpanthenol is an important therapeutic agent with antioxidant and anti-inflammatory effects. In the study, anti-inflammatory and antioxidant properties of dexpanthenol were evaluated in the acute respiratory distress model created using oleic acid. Material and Method: For this purpose, 50 female Wistar-albino rats were divided into five groups (n:10). The groups were named as Control (C), Oleic acid (O), Dexpanthenol+Oleic acid (DO), Dexpanthenol+Oleic acid+Despanthenol (DOD) and Oleic acid+Dexpanthenol (OD). After the rats were sacrificed, levels of interleukin-1α and Tumor Necrosis Factor-alpha in serum samples were determined. In the lung tissue, histopathological examination and measurements of malondialdehyde tissue, glutathione peroxidase, catalase enzyme activity levels were made with light microscopy. Results: The results obtained showed that histopathologically significant acute lung injury was detected in the group that was not treated with oleic acid. Biochemical analyzes performed on tissue samples support histopathological results. Results from treatment groups show that the damage caused by oleic acid decreases with dexpanthenol treatment. Especially MDA levels as oxidative parameter and CAT and GSH levels as antioxidant parameters show the effect of oxidative damage.Conclusions: In conclusion, it is thought that the application of dexpanthenol is effective in preventing the development of experimental acute respiratory distress syndrome, and this effect is due to the anti-inflammatory and antioxidant properties of dexpanthenol. |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Süleyman Demirel Üniversitesi |
|
| dc.publisher |
Süleyman Demirel University |
|
| dc.relation |
https://dergipark.org.tr/tr/download/article-file/1614961 |
|
| dc.source |
Volume: 12, Issue: 2
192-199 |
en-US |
| dc.source |
2146-247X |
|
| dc.source |
Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi |
|
| dc.subject |
Akut akciğer hasarı,Anti-inflamatuvar,Antioksidan,Dekspantenol,Oleik asit |
|
| dc.subject |
Acute lung injury,Anti-inflammatory,Antioxidant,Dexpanthenol,Oleic acid |
|
| dc.title |
Deneysel Akut Respiratuar Distres Modelinde Dekspantenol’ün Anti-İnflamatuvar ve Antioksidan Etkilerinin Araştırılması |
tr-TR |
| dc.title |
Anti-Inflammatory and Antioxidant Effects of Dexpantenol on the Experimental Acute Respiratory Distress Model |
en-US |
| dc.type |
info:eu-repo/semantics/article |
|
| dc.citation |
Repine JE. Scientific perspectives on adult respiratory distress syndrome. Lancet 1992; 339: 466-469. |
|
| dc.citation |
Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, et al. The AmericanEuropean Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med 1998; 157 (4 Pt 1): 1332-1347. |
|
| dc.citation |
McGuigan, C. Acute lung injury using oleic acid in the laboratory rat: establishment of a working model and evidence against free radicals in the acute phase. Current Surgery 2003; 60 (4): 412-417. |
|
| dc.citation |
Park SY, Kim HJ, Yoo KH, Park BY, Kim WS, Lee SJ, et al. The efficacy and safety of prone positioning in adults patients with acute respiratory distress syndrome: A meta-analysis of randomized controlled trials. J Thorac Dis 2015; 7: 356–367. |
|
| dc.citation |
Rezoagli E, Fumagalli R, Bellani G. Definition and epidemiology of acute respiratory distress syndrome. Ann Transl Med 2017; 5: 282. |
|
| dc.citation |
Lanken P. Acute respiratory distress syndrome L. PN, Editor. W.B. Saunders: Philadelphia; 2001. |
|
| dc.citation |
Marino P. Acute respiratory distress syndrome, in The ICU book. Lipincott Williams & Wilkins: Philadelphia. 2007; p: 419-35. |
|
| dc.citation |
Schuster DP. ARDS: clinical lessons from the oleic acid model of acute lung injury. Am J Respir Crit Care Med 1994; 149 (1): 245-260. |
|
| dc.citation |
Kulikov AU, Zinchenko AA. Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations. J.Pharm. Biomed. Anal. 2007; 43 (3): 983-988. |
|
| dc.citation |
Goodman LS, Gilman AG, Rall TW, Nies AS, Taylor P. Goodman and Gilman’s The pharmacological basis of therapeutics. Eighth edition. U.s.a: Pergamon pres 1990; 1540- 1541. |
|
| dc.citation |
Ozdulger A, Cinel I, Koksel O, Cinel L, Avlan D, Unlu A, et al. The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. Shock 2003; 19 (4): 366-372. |
|
| dc.citation |
Yoshida T, Fujino Y, Amato MB, Kavanagh BP. Fifty years of research in ARDS. Spontaneous breathing during mechanical ventilation. Risks, mechanisms, and management. Am J Respir Crit Care Med. 2017; 195(8): 985-92. |
|
| dc.citation |
Koksel O, Kaplan MB, Ozdulger A, Tamer L, Degirmenci U, Cinel L, et al. Oleic acid-induced lung injury in rats and effects of caffeic acid phenethyl ester. Exp Lung Research 2005; 31: 483-496. |
|
| dc.citation |
Kennedy MT, Higgins BD, Costello JF, Curtin WA, Laffey JG. Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury. BMC Pulmonary Medicine 2008; 8: 9. |
|
| dc.citation |
Chen HI, Hsieh N, Kao SJ, Su CF. Protective affects of propofol on acute lung injury induced by oleic acid in conscious rats. Crit Care Med 2008; 36 (4). |
|
| dc.citation |
Zhu GF, Sun B, Niu SF, Cai YY, Lindwall R, Robertson B. Combined surfactant therapy and ınhaled nıtrıc oxide in rabbits with oleic acid-induced acute respiratory distress syndrome. Am J Respir Crit Care Med 1998; 158: 437-443. |
|
| dc.citation |
Rebecca M, McGuigan, Philip Mullenix, Lewis L. Norlund. Acute lung injury using oleic acid in the laboratory rat: establishment of a working model and evidence against free radicals in the acute phase. Current Surgery 2003; 60: 4. |
|
| dc.citation |
Liu H, Zhang D, Zhao B, Zhao J. Superoxide anion, the main species of ROS in the development of ARDS induced by oleic acid. Free Radic Res 2004; 38: 1281-1287. |
|
| dc.citation |
Meyancı Köksal G, Sayılgan C, Finci A, Uzan S, Oz H. Akut akciğer hasarının tedavisinde erken dönemde intratrakeal PG E1’in lipid peroksidasyonu üzerine etkisi. GKD Anestezi Yoğun Bakım Derneği Dergisi 2004; 10: 108-110. |
|
| dc.citation |
Altintas R, Parlakpinar H, Beytur A, Vardi N, Polat A, Sagir M, et al. Protective Effect of Dexpanthenol on Ischemia-Reperfusion-Induced Renal Injury in Rats. Kidney Blood Press Res 2012; 36: 220-230. |
|
| dc.citation |
Velmurugan B, Bhuvaneswari V, Burra UK, Nagini S. Prevention of Nmethyl- N'-nitroN-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene. Eur J Cancer Prev 2002; 11: 19-26. |
|
| dc.citation |
Gadek JE, Pacht ER. The interdependence of lung antioxidants and antiprotease defense in ARDS. Chest 1996; 110 (Suppl.6): 273-277. |
|
| dc.citation |
Leff JA, Parsons PE, Day CE, Taniguchi N, Jochum M, Fritz H, et al. Serum antioxidants as predictors of adult respiratory distress syndrome in patients with sepsis. Lancet 1993; 341: 777- 780. |
|
| dc.citation |
Metnitz PG, Bartens C, Fischer M, Fridrich P, Steltzer H, Druml W. Antioxidant status in patients with acute respiratory distress syndrome. Intensive Care Med. 1999; 25: 180-185. |
|
| dc.citation |
Bulmuş FG, Gürsu MF, Muz HM, Yaman İ, Bulmuş Ö, Sakin F. Protective Effects of Alpha-Lipoic Acid on Oleic Acid-Induced Acute Lung Injury in Rats. Balkan Med J 2013; 30: 309-314. |
|
| dc.citation |
Salman AE, Yetişir F, Kılıç M, Önal Ö, Dostbil A, Zeybek D. The impact of pretreatment with bolus dose of enteral glutamine on acute lung injury induced by oleic acid in rats. J Anesth 2014; 28: 354–362. |
|
| dc.citation |
De Nardin E. The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease. Annals of periodontology 2001; 6 (1): 30-40. |
|
| dc.citation |
Madtes DK, Klima LD, Ruberfeld G. Elevated Transforming Growth Factor-α levels in bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1998; 158: 424-430 |
|
| dc.citation |
Velmurugan B, Nagini S. Combination chemoprevention of experimental gastric carcinogenesis by s-allylcysteine and lycopene: modulatory effects on glutathione redox cycle antioxidants. J Med Food 2005; 8: 494-501. |
|