| dc.creator |
Yilmaz, HR |
|
| dc.creator |
Kotuk, M |
|
| dc.creator |
Sogut, S |
|
| dc.creator |
Ozyurt, H |
|
| dc.creator |
Ulu, R |
|
| dc.creator |
Yildirim, Z |
|
| dc.date |
2004-05-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:46:38Z |
|
| dc.date.available |
2021-12-03T11:46:38Z |
|
| dc.identifier |
a796720a-1088-4176-a47e-b8f675d843d3 |
|
| dc.identifier |
10.1002/cbf.1069 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/a796720a-1088-4176-a47e-b8f675d843d3/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/93982 |
|
| dc.description |
The aim of this experimental study was to investigate the possible role of adenosine deaminase (AD) and xanthine oxidase (XO) in the pathogenesis of cisplatin-induced nephrotoxicity and the effect of erdosteine in decreasing the toxicity. The intraperitoneal injection of cisplatin (7m kg(-1) body weight) induced a significant increase in plasma creatinine level and blood urea nitrogen (BUN), and plasma and damaged renal tissue activities of AD and XO in rats. Co-treatment with erdosteine (10 mg kg(-1) day(-1)) attenuated the increase in the plasma creatinine and BUN levels, and significantly prevented the increase in tissue and plasma AD and XO activities (P < 0.05). The results of this study revealed that XO and AD may play an important role in the pathogenesis of cisplatin-induced nephrotoxicity. The potent free radical scavenger erdosteine may have protective potential in this process and it will become a promising drug in the prevention of this undesired side-effect of cisplatin. but further studies are needed to illuminate the exact protection mechanism of erdosteine against cisptatin-induced nephrotoxicity. Copyright (C) 2004 John Wiley Sons, Ltd. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
In vivo evidence suggesting a role for purine-catabolizing enzymes in the pathogenesis of cisplatin-induced nephrotoxicity in rats and effect of erdosteine against this toxicity |
|
| dc.type |
info:eu-repo/semantics/article |
|