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Prostate Cancer: Signal Mechanism of Androgen Receptor

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dc.creator ERZURUMLU, Yalçın; SÜLEYMAN DEMİREL ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, TEMEL ECZACILIK BİLİMLERİ BÖLÜMÜ, BİYOKİMYA ANABİLİM DALI
dc.date 2021-03-11T00:00:00Z
dc.date.accessioned 2021-12-03T11:46:54Z
dc.date.available 2021-12-03T11:46:54Z
dc.identifier https://dergipark.org.tr/tr/pub/sdutfd/issue/60659/726163
dc.identifier 10.17343/sdutfd.726163
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94125
dc.description Prostate cancer is the second most common form of cancer in male individuals, resulting in the death of individuals. It is known that cells require androgens in normal prostate and prostate cancer development. Androgens initiate the specialized transcriptional process by stimulating the androgen receptor, a member of the steroid-nuclear receptor superfamily in cells. It is known that prostate cancer develops due to the androgen receptor signal that is impaired for various reasons. In this review, information about general features of prostate cancer, cellular androgens, and molecular structure of androgen receptor is summarized. In addition, the mechanism of signal transduction regulated by direct androgen stimulation of the androgen receptor and alternative signaling mechanisms mediated by growth factors, interleukins or proteins that are members of the kinase family will be summarized and discussed in detail.
dc.description Prostat kanseri erkek bireylerde cilt kanserinden sonra en sık rastlanan ve bireylerin yaşamını yitirmesi ile sonuçlanan ikinci kanser türüdür. Normal prostat ve prostat kanseri gelişiminde hücrelerinin androjenlere gerek duyduğu bilinmektedir. Androjenler hücrelerdeki steroid-nüklear reseptör süper ailesi üyesi olan androjen reseptörünü uyararak özelleşmiş transkripsiyonel süreci başlatmaktadır. Çeşitli nedenlerle bozulan androjen reseptörü sinyali nedeniyle prostat kanserinin geliştiği bilinmektedir. Bu derlemede prostat kanserinin genel özellikleri, hücresel androjenler ve androjen reseptörünün moleküler yapısı hakkında bilgiler özetlenmiştir. Ayrıca prostat kanseri hücrelerinin kullandığı iki majör mekanizma; androjen reseptörünün doğrudan androjen uyarımı ile düzenlenen sinyal iletiminin mekanizması ve büyüme faktörleri, interlökinler ya da kinaz ailesinin üyesi olan proteinler aracılı olarak kontrol edilen alternatif sinyal mekanizmaları özetlenerek detayları tartışılmıştır.
dc.format application/pdf
dc.language tr
dc.publisher Süleyman Demirel Üniversitesi
dc.publisher Süleyman Demirel University
dc.relation https://dergipark.org.tr/tr/download/article-file/1068841
dc.source Volume: 28, Issue: 1 187-198 en-US
dc.source 1300-7416
dc.source 2602-2109
dc.source SDÜ Tıp Fakültesi Dergisi
dc.subject prostate cancer,androgen receptor,androgen
dc.subject prostat kanseri,androjen reseptörü,androjen
dc.title Prostate Cancer: Signal Mechanism of Androgen Receptor en-US
dc.title Prostat Kanseri: Androjen Reseptörü Sinyal Mekanizması tr-TR
dc.type info:eu-repo/semantics/article
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