| dc.creator |
RASULOVA, Khayala; DOKUZ EYLÜL ÜNİVERSİTESİ |
|
| dc.creator |
PEHLİVAN, Melek; izmir Katip Çelebi Üniversitesi |
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| dc.creator |
DİLEK, Banu; DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ |
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| dc.creator |
KIZILDAĞ, Sefa; DOKUZ EYLÜL ÜNİVERSİTESİ |
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| dc.date |
2021-09-13T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:46:56Z |
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| dc.date.available |
2021-12-03T11:46:56Z |
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| dc.identifier |
https://dergipark.org.tr/tr/pub/sdutfd/issue/64881/792825 |
|
| dc.identifier |
10.17343/sdutfd.792825 |
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| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94153 |
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| dc.description |
Fibromyalgia syndrome (FMS) is a chronic musculoskeletalpain disorder associated with other symptoms.It is mainly characterized by pain, fatigue, and sleepdisturbance. Many other genetic, immunological, andhormonal factors play an important role in the etiologyof fibromyalgia. This pathological condition affectsapproximately 3-10% of the population. The incidenceof the disease is more often in women. Women showmore severe symptoms and lower pain threshold thanmen. Therefore, most of the research has focused onfemale subjects.MicroRNAs (miRNAs) regulate at least 30% ofhuman genes. In recent years, miRNAs have beenidentified as important modulators of gene expressionin disease processes and physiological pathways.However, each microRNA may be responsible forregulation of hundreds of genes. miRNAs inhibit thegene expression after transcription through inhibitionof translation or degradation of target messenger RNA.The purpose of this review is to discuss the role ofmiRNAs in FMS disease. According to the studies,some miRNA expression levels were changed in FMSpatients. The presence of microRNAs in differentcellular compartments and their extracellular stabilitymake them interesting candidate biomarkers for betterunderstanding the etiology of complex diseases suchas FMS. |
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| dc.description |
Fibromiyalji sendromu (FMS), diğer semptomlarla ilişkilikronik kas-iskelet sistemi ağrı bozukluğudur. Esasolarak ağrı, yorgunluk ve uyku bozukluğu ile karakterizedir.Fibromiyaljinin etiyolojisinde genetik, immünolojikve hormonal birçok faktör önemli rol oynamaktadır.Bu patolojik durum popülasyonun yaklaşık %3-10'unuetkilemektedir. Görülme sıklığı açısından, kadınlardaerkeklerden daha fazla görülmektedir. Kadınlar erkeklerdendaha şiddetli belirtiler ve daha düşük ağrı eşiğigöstermektedir. Bu yüzden araştırmaların çoğu kadındeneklere odaklanmıştır.MikroRNA'lar (miRNA), insan genlerinin en az %30'unu düzenlemektedirler. Son yıllarda miRNA’lar hastalıksüreçlerinde ve fizyolojik yolaklarda gen ekspresyonununönemli modülatörleri olarak tanımlanmıştır.Bununla birlikte her miRNA yüzlerce genin regülasyonundansorumlu olabilir. miRNA’lar translasyonunengellenmesi veya hedef haberci RNA'nın yıkımı yoluylatranskripsiyon sonrası gen ekspresyonunu inhibeederler.Bu derlemenin amacı miRNA’ların FMS hastalığındakirolünü tartışmaktır. Yapılan çalışmalara göre, FMShastalarında bazı miRNA ekspresyon düzeylerinindeğiştiği saptanmıştır. Farklı hücresel bölmelerdekimiRNA'ların varlığı ve hücre dışı ortamdaki kararlılıkları,FMS gibi karmaşık hastalıkların etiyolojisini dahaiyi anlamak için onları ilgi çekici aday biyobelirteçleryapmaktadır. |
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| dc.format |
application/pdf |
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| dc.language |
tr |
|
| dc.publisher |
Süleyman Demirel Üniversitesi |
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| dc.publisher |
Süleyman Demirel University |
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| dc.relation |
https://dergipark.org.tr/tr/download/article-file/1282497 |
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| dc.source |
Volume: 28, Issue: 3
529-533 |
en-US |
| dc.source |
1300-7416 |
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| dc.source |
2602-2109 |
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| dc.source |
SDÜ Tıp Fakültesi Dergisi |
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| dc.subject |
Fibromyalgia,miRNA,biomarkers |
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| dc.subject |
Fİbromyalji,miRNA,biyobelirteç |
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| dc.title |
THE ROLE AND IMPORTANCE OF miRNA PROFILES IN PATIENTS WITH FIBROMYALGIA SYNDROME |
en-US |
| dc.title |
FİBROMİYALJİ SENDROMU OLAN HASTALARDA miRNA PROFİLLERİNİN ROLÜ VE ÖNEMİ |
tr-TR |
| dc.type |
info:eu-repo/semantics/article |
|
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