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The Effects of Tl-201 Myocardial Perfusion Scintigraphy Studies on Oxidative Damage in Patients

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dc.creator Delibas, N.
dc.creator Cicek, E.
dc.creator Yildiz, M.
dc.creator Bahceli, S.
dc.date 2009-01-01T01:00:00Z
dc.date.accessioned 2021-12-03T11:46:59Z
dc.date.available 2021-12-03T11:46:59Z
dc.identifier ad2604e5-bf79-46f8-b574-4d6ec75a28de
dc.identifier https://avesis.sdu.edu.tr/publication/details/ad2604e5-bf79-46f8-b574-4d6ec75a28de/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94186
dc.description The aim of this study was to investigate gamma radiation-induced oxidative damage in erythrocytes after Tl-201 myocardial perfusion scintigraphy. Twenty patients (8 women and 12 men) who performed Tl-201 myocardial perfusion scintigraphy were included in this study. The blood samples re taken from patients just before, I hour after and three hours after injection of the radiopharmaceutical. Malondialdehyde (MDA) and antioxidant enzymes such as glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT) levels were measured to evaluate the gamma radiation induced oxidative damage. The enzyme activities of SOD, GPX and CAT were decreased I hour after (p = 0.042, p = 0.697 and p = 0.653 respectively) and 3 hours after (p = 0.003, p = 0.5 73 and p = 0.002 respectively) injection of the radiopharmaceutical. Malondialdehyde levels were increased I hour after (p = 0.10) and 3 hours after (p = 0.47) injection of the radiopharmaceutical. In this study, we found that radiation due to Tl-201 myocardial perfusion scintigraphy decreased the erythrocyte antioxidant levels and increased MDA levels.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title The Effects of Tl-201 Myocardial Perfusion Scintigraphy Studies on Oxidative Damage in Patients
dc.type info:eu-repo/semantics/article


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