| dc.creator |
AYVAZ, Havva Hilal; SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR. |
|
| dc.creator |
KORKMAZ, Selma; SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR. |
|
| dc.creator |
ERTURAN, İjlal; SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR. |
|
| dc.creator |
YILDIRIM, Mehmet; SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR. |
|
| dc.creator |
ATAY, Emrah; TIP PR. |
|
| dc.date |
2021-09-13T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:47:00Z |
|
| dc.date.available |
2021-12-03T11:47:00Z |
|
| dc.identifier |
https://dergipark.org.tr/tr/pub/sdutfd/issue/64881/791681 |
|
| dc.identifier |
10.17343/sdutfd.791681 |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94214 |
|
| dc.description |
AmaçSistemik oral isotretinoin, orta-şiddetli akne vulgaris vetedaviye dirençli hafif akne vulgaris tedavisinde yıllardırkullanılan etkin bir tedavidir. İsotretinoin tedavisininbirçok yan etkisi bildirilmiş olup, gün geçtikçe yeni yanetkileri de ortaya çıkmaktadır. Bu çalışmada, isotretinointedavisinin birçok hastalıkla ilişkili değerlendirilebilenbelirteçler olan serum ürik asit ve MPV düzeylerindedeğişime neden olup olmadığının araştırılmasıamaçlandı.Gereç ve YöntemHastanemiz Dermatoloji Polikliniğine başvuran, enaz üç ay önce isotretinoin tedavisi başlanmış olan vekontrollerini aksatmayan, hafif-orta veya şiddetli aknevulgaris tanısı almış 78 hasta çalışmaya alındı. Standartolarak yaklaşık 0,5 mg/kg/gün dozda isotretinointedavisi başlanan hastaların tedavi öncesi ve tedavinin3. ayındaki hemogram parametreleri, lipit düzeyleri,monosit/HDL oranı ve MPV ile ürik asit düzeyleriincelendi.BulgularHastaların tedavi öncesi ve tedavinin 3. ayında bakılanhemogram parametreleri, MPV ve ürik asit düzeyleriarasında herhangi bir anlamlı değişiklik saptanmamışken(p>0,05); lipit düzeyleri arasında (trigliserit, totalkolesterol, LDL) anlamlı farklılıklar mevcuttu (p |
|
| dc.description |
ObjectiveOral isotretinoin is an effective treatment used for yearsin the treatment of acne vulgaris. Many side effectsof it have been reported, and new ones appear dayby day. In this study, it was aimed to investigate whetherisotretinoin causes changes in serum uric acid andMPV levels, which are markers that can be evaluatedin many diseases.Material and Methods78 patients who were admitted to Dermatology OutpatientClinic of our hospital and were diagnosed withmild to moderate or severe acne vulgaris and to whomisotretinoin treatment was started at least three monthsago, were included in this study. Hemogram parameters,lipid levels, monocyte / HDL ratio, MPV anduric acid levels were examined before treatment andat the third month of treatment in patients who startedisotretinoin at a dose of approximately 0.5 mg / kg /day as a standard.ResultsWhile there was no significant change between the hemogramparameters, MPV and uric acid levels of thepatients before and in the third month of treatment (p>0.005); there were significant differences between lipidlevels (triglyceride, total cholesterol, LDL) (p |
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| dc.format |
application/pdf |
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| dc.language |
tr |
|
| dc.publisher |
Süleyman Demirel Üniversitesi |
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| dc.publisher |
Süleyman Demirel University |
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| dc.relation |
https://dergipark.org.tr/tr/download/article-file/1278502 |
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| dc.source |
Volume: 28, Issue: 3
397-402 |
en-US |
| dc.source |
1300-7416 |
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| dc.source |
2602-2109 |
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| dc.source |
SDÜ Tıp Fakültesi Dergisi |
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| dc.subject |
Akne,İsotretinoin,ürik asit,ortalama trombosit hacmi |
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| dc.subject |
Acne,isotretinoin,uric acid,MPV |
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| dc.title |
AKNE VULGARİS HASTALARINDA İSOTRETİNOİN TEDAVİSİNİN SERUM ÜRİK ASİT VE ORTALAMA TROMBOSİT HACMİ (MPV) ÜZERİNE OLAN ETKİLERİNİN ARAŞTIRILMASI |
tr-TR |
| dc.title |
EVALUATION OF THE EFFECTS OF ISOTRETINOIN TREATMENT ON SERUM URIC ACID AND MEAN PLATELET VOLUME IN PATIENTS WITH ACNE VULGARIS |
en-US |
| dc.type |
info:eu-repo/semantics/article |
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