| dc.creator |
Altinbas, Mustafa |
|
| dc.creator |
Arsav, Vedat |
|
| dc.creator |
Er, Ozlem |
|
| dc.creator |
Coskun, H. Senol |
|
| dc.creator |
Soyuer, Serdar |
|
| dc.creator |
Canoz, Ozlem |
|
| dc.creator |
Ozkan, Metin |
|
| dc.date |
2006-09-01T00:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:54:15Z |
|
| dc.date.available |
2021-12-03T11:54:15Z |
|
| dc.identifier |
b9a8c9cc-58e1-4ff8-87c1-dfa411460e5a |
|
| dc.identifier |
10.1007/s00408-005-2591-y |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/b9a8c9cc-58e1-4ff8-87c1-dfa411460e5a/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94518 |
|
| dc.description |
The aim of this study was to determine the incidence and role of c-erbB-2 overexpression as a predictive/prognostic marker in small-cell lung carcinoma (SCLC). We performed a retrospective study on subjects with a biopsy-proven diagnosis of SCLC. A chart review for demographic and clinical data was performed on patients with SCLC diagnosed between 1998 and 2004. c-erbB-2 overexpression was evaluated using immunohistochemistry performed on archival paraffin-embedded specimens. Sixty-seven patients with SCLC were identified (6 females, 61 males; median age- 56.5 yr, range-34-75) all of whom had adequate tissue specimens available for c-erB-2 testing. Of the 67 specimens, 12 (17.9%) showed c-erbB-2 overexpression. Seventy-five of the cases were positive for c-erbB-2, had extensive disease. The median overall survival of patients with SCLC whose tumors were positive and negative for c-erbB-2 were 8 +/- 0.9 months (95%CI 6.3-9.7) and 11 +/- 1.5 months (95%CI 8.0-14.0), respectively. c-erbB-2 overexpression detected using immunohistochemistry is observed in 17.9% of patients with SCLC and has statistically significant prognostic value. Our findings suggest that c-erbB-2 may be a potential target for site-specific immunotherapy in SCLC. Considering one technique examined, further molecular investigation is needed to confirm these preliminary findings. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
The role of c-erbB-2 expression on the survival of patients with small-cell lung cancer |
|
| dc.type |
info:eu-repo/semantics/article |
|