| dc.creator |
Ceylan, C. |
|
| dc.creator |
Serel, T. A. |
|
| dc.creator |
Ceylan, G. G. |
|
| dc.date |
2010-01-01T01:00:00Z |
|
| dc.date.accessioned |
2021-12-03T11:54:23Z |
|
| dc.date.available |
2021-12-03T11:54:23Z |
|
| dc.identifier |
bc172b1c-138c-412f-939f-19395cd52a3a |
|
| dc.identifier |
10.4238/vol9-2gmr826 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/bc172b1c-138c-412f-939f-19395cd52a3a/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94567 |
|
| dc.description |
We looked for a possible association between Klinefelter syndrome (KFS) and microdeletions in the Y chromosome in Turkish KFS patients. We examined the frequency of KFS in male patients with proven non-obstructive azoospermia and the types of Y chromosome microdeletions in these KFS patients. Fifty azoospermic patients and 50 fertile men were included in this study. KFS was found in 14 azoospermic patients. Y chromosome microdeletions were found in eight KFS patients. Azoospermia factor locus c (AZFc) was the most commonly deleted interval in KFS patients. All KFS patients had elevated plasma follicle-stimulating hormone and luteinizing hormone concentrations, but they had normal plasma testosterone concentrations. Testis biopsy of five samples with Y microdeletions revealed Sertoli cell-only syndrome. No Y microdeletions were found in the fertile group. We concluded that there could be an association between the AZFc region and KFS. Screening for this should be part of diagnostic work-up, particularly in those considering assisted reproduction. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
The azoospermia factor locus-c region was found to be related to Klinefelter syndrome in Turkish patients |
|
| dc.type |
info:eu-repo/semantics/article |
|